2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. 5α-Androstane-3β,5,6β-triol

5α-Androstane-3β,5,6β-triol 

Cat. No.: HY-100206 Purity: 99.74%
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5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo.

For research use only. We do not sell to patients.

5α-Androstane-3β,5,6β-triol Chemical Structure

5α-Androstane-3β,5,6β-triol Chemical Structure

CAS No. : 4725-51-3

Size Price Stock Quantity
1 mg USD 31 In-stock
5 mg USD 110 In-stock
10 mg USD 175 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

5α-Androstane-3β,5,6β-triol Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo[1].

IC50 & Target

AMPK[1]
Molecular Weight

308.46

Formula

C19H32O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12CCC[C@@]1([H])[C@]3([H])C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (405.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2419 mL 16.2096 mL 32.4191 mL
5 mM 0.6484 mL 3.2419 mL 6.4838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2419 mL 16.2096 mL 32.4191 mL 81.0478 mL
5 mM 0.6484 mL 3.2419 mL 6.4838 mL 16.2096 mL
10 mM 0.3242 mL 1.6210 mL 3.2419 mL 8.1048 mL
15 mM 0.2161 mL 1.0806 mL 2.1613 mL 5.4032 mL
20 mM 0.1621 mL 0.8105 mL 1.6210 mL 4.0524 mL
25 mM 0.1297 mL 0.6484 mL 1.2968 mL 3.2419 mL
30 mM 0.1081 mL 0.5403 mL 1.0806 mL 2.7016 mL
40 mM 0.0810 mL 0.4052 mL 0.8105 mL 2.0262 mL
50 mM 0.0648 mL 0.3242 mL 0.6484 mL 1.6210 mL
60 mM 0.0540 mL 0.2702 mL 0.5403 mL 1.3508 mL
80 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0131 mL
100 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8105 mL
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5α-Androstane-3β,5,6β-triol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5α-Androstane-3β,5,6β-triol4725-51-3AMPKAMP-activated protein kinaseneuronal injurycerebral arteryinfarctneurologic impairmentInhibitorinhibitorinhibit

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