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  4. Lactic Acid Metabolic Compound Library
Lactic Acid Metabolic Compound Library

Cat. No.: HY-L204

Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism.

MCE contains 330 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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  • Product Details
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Description & Advantages

•   A unique collection of 330 lactic acid metabolic related compounds.

•   A useful tool for cancer, cardiovascular disease, metabolic disease drugs discovery.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 330 lactic acid metabolism related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 324 compounds supplied in 10 mM solution, 5 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

AMPK (81)

c-Myc (24)

PDHK (9)

Akt (7)

mTOR (4)

PPAR (4)

COX (3)

ERK (3)

HIV (3)

MMP (3)

PKA (3)

STAT (3)

AP-1 (2)

FAK (2)

HDAC (2)

JNK (2)

PARP (2)

PI3K (2)

Wnt (2)

AIM2 (1)

ASCT (1)

CDK (1)

CFTR (1)

EGFR (1)

FLT3 (1)

HBV (1)

HSP (1)

HSV (1)

JAK (1)

KLF (1)

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  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Lactic Acid Metabolic Compound Library
    Cat. No.:
    HY-L204
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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