2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 6-Chloroguanineriboside

6-Chloroguanineriboside  (Synonyms: 6-Chloroguanosine)

Cat. No.: HY-W009234 Purity: ≥98.0%
SDS COA Handling Instructions

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6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

6-Chloroguanineriboside Chemical Structure

6-Chloroguanineriboside Chemical Structure

CAS No. : 2004-07-1

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Based on 1 publication(s) in Google Scholar

6-Chloroguanineriboside Related Antibodies

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Description

6-Chloroguanineriboside (6-Chloroguanosine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
Vero IC50
> 300 μM
Compound: 5
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
[PMID: 17336519]
Molecular Weight

301.69

Formula

C10H12ClN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)N=C3Cl)=C3N=C2)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (331.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3147 mL 16.5733 mL 33.1466 mL
5 mM 0.6629 mL 3.3147 mL 6.6293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (252 KB) HNMR (99 KB) OR (206 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3147 mL 16.5733 mL 33.1466 mL 82.8665 mL
5 mM 0.6629 mL 3.3147 mL 6.6293 mL 16.5733 mL
10 mM 0.3315 mL 1.6573 mL 3.3147 mL 8.2867 mL
15 mM 0.2210 mL 1.1049 mL 2.2098 mL 5.5244 mL
20 mM 0.1657 mL 0.8287 mL 1.6573 mL 4.1433 mL
25 mM 0.1326 mL 0.6629 mL 1.3259 mL 3.3147 mL
30 mM 0.1105 mL 0.5524 mL 1.1049 mL 2.7622 mL
40 mM 0.0829 mL 0.4143 mL 0.8287 mL 2.0717 mL
50 mM 0.0663 mL 0.3315 mL 0.6629 mL 1.6573 mL
60 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3811 mL
80 mM 0.0414 mL 0.2072 mL 0.4143 mL 1.0358 mL
100 mM 0.0331 mL 0.1657 mL 0.3315 mL 0.8287 mL
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6-Chloroguanineriboside Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Chloroguanineriboside2004-07-16-ChloroguanosineNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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