6-Thioguanosine (Synonyms: 6-Mercaptoguanosine)

Cat. No.: HY-119499 Purity: 98.23%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects.

For research use only. We do not sell to patients.

6-Thioguanosine Chemical Structure

CAS No. : 85-31-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 44	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 44	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects^[1].

Molecular Weight

299.31

Formula

C₁₀H₁₃N₅O₄S

CAS No.

85-31-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC(C2=C(N1)N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (66.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3410 mL	16.7051 mL	33.4102 mL
5 mM	0.6682 mL	3.3410 mL	6.6820 mL
10 mM	0.3341 mL	1.6705 mL	3.3410 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.23%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (250 KB) HNMR (282 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Amedeo De Nicolò, et al. UPLC-MS/MS method for quantification of the azathioprine metabolites 6-mercaptoguanosine and 6-methylmercaptopurine riboside in peripheral blood mononuclear cells. J Pharm Biomed Anal. 2014 Sep;98:271-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3410 mL	16.7051 mL	33.4102 mL	83.5254 mL
	5 mM	0.6682 mL	3.3410 mL	6.6820 mL	16.7051 mL
	10 mM	0.3341 mL	1.6705 mL	3.3410 mL	8.3525 mL
	15 mM	0.2227 mL	1.1137 mL	2.2273 mL	5.5684 mL
	20 mM	0.1671 mL	0.8353 mL	1.6705 mL	4.1763 mL
	25 mM	0.1336 mL	0.6682 mL	1.3364 mL	3.3410 mL
	30 mM	0.1114 mL	0.5568 mL	1.1137 mL	2.7842 mL
	40 mM	0.0835 mL	0.4176 mL	0.8353 mL	2.0881 mL
	50 mM	0.0668 mL	0.3341 mL	0.6682 mL	1.6705 mL
	60 mM	0.0557 mL	0.2784 mL	0.5568 mL	1.3921 mL

6-Thioguanosine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Thioguanosine85-31-46-MercaptoguanosineNucleoside Antimetabolite/Analogimmunosuppressiveactive nucleosideInhibitorinhibitorinhibit

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