7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

Name: 7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene
Brand: MedChemExpress
SKU: HY-135589
Rating: 4.5 (1 reviews)

Cat. No.: HY-135589 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

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7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC₅₀ of 3.1 μM.

For research use only. We do not sell to patients.

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene Chemical Structure

CAS No. : 1159977-58-8

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC₅₀ of 3.1 μM^[1].

In Vitro

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is binding to the domain (LBD) of LRH-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

704.87

Formula

C₄₂H₄₄N₂O₆S

CAS No.

1159977-58-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C(C2=C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)C5=CC=C(O)C(C(C6=CC=C(OCCN7CCCCC7)C=C6)=O)=C5S2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (141.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4187 mL	7.0935 mL	14.1870 mL
5 mM	0.2837 mL	1.4187 mL	2.8374 mL
10 mM	0.1419 mL	0.7094 mL	1.4187 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) HNMR (412 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)

References

[1]. Rey, J., et al. Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation. ChemMedChem,2012; 7(11), 1909–1914.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4187 mL	7.0935 mL	14.1870 mL	35.4675 mL
	5 mM	0.2837 mL	1.4187 mL	2.8374 mL	7.0935 mL
	10 mM	0.1419 mL	0.7094 mL	1.4187 mL	3.5468 mL
	15 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3645 mL
	20 mM	0.0709 mL	0.3547 mL	0.7094 mL	1.7734 mL
	25 mM	0.0567 mL	0.2837 mL	0.5675 mL	1.4187 mL
	30 mM	0.0473 mL	0.2365 mL	0.4729 mL	1.1823 mL
	40 mM	0.0355 mL	0.1773 mL	0.3547 mL	0.8867 mL
	50 mM	0.0284 mL	0.1419 mL	0.2837 mL	0.7094 mL
	60 mM	0.0236 mL	0.1182 mL	0.2365 mL	0.5911 mL
	80 mM	0.0177 mL	0.0887 mL	0.1773 mL	0.4433 mL
	100 mM	0.0142 mL	0.0709 mL	0.1419 mL	0.3547 mL