7-Methoxy-4-methyl-coumarin-8-ol

Name: 7-Methoxy-4-methyl-coumarin-8-ol
Brand: MedChemExpress
SKU: HY-N10015
Rating: 4.5 (1 reviews)

Cat. No.: HY-N10015 Purity: 99.92%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound isolated from sour orange (Citrus aurantium).

For research use only. We do not sell to patients.

7-Methoxy-4-methyl-coumarin-8-ol Chemical Structure

CAS No. : 22084-94-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound isolated from sour orange (Citrus aurantium)^[1].

Molecular Weight

206.19

Formula

C₁₁H₁₀O₄

CAS No.

22084-94-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C)C2=CC=C(OC)C(O)=C2O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (484.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8499 mL	24.2495 mL	48.4990 mL
5 mM	0.9700 mL	4.8499 mL	9.6998 mL
10 mM	0.4850 mL	2.4249 mL	4.8499 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (268 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. LingrongWen, et al. Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8499 mL	24.2495 mL	48.4990 mL	121.2474 mL
	5 mM	0.9700 mL	4.8499 mL	9.6998 mL	24.2495 mL
	10 mM	0.4850 mL	2.4249 mL	4.8499 mL	12.1247 mL
	15 mM	0.3233 mL	1.6166 mL	3.2333 mL	8.0832 mL
	20 mM	0.2425 mL	1.2125 mL	2.4249 mL	6.0624 mL
	25 mM	0.1940 mL	0.9700 mL	1.9400 mL	4.8499 mL
	30 mM	0.1617 mL	0.8083 mL	1.6166 mL	4.0416 mL
	40 mM	0.1212 mL	0.6062 mL	1.2125 mL	3.0312 mL
	50 mM	0.0970 mL	0.4850 mL	0.9700 mL	2.4249 mL
	60 mM	0.0808 mL	0.4042 mL	0.8083 mL	2.0208 mL
	80 mM	0.0606 mL	0.3031 mL	0.6062 mL	1.5156 mL
	100 mM	0.0485 mL	0.2425 mL	0.4850 mL	1.2125 mL