ATWLPPR Peptide TFA

Name: ATWLPPR Peptide TFA
Brand: MedChemExpress
SKU: HY-P1663A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1663A Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF₁₆₅ binding to NRP-1, used in the research of angiogenesis. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes.

For research use only. We do not sell to patients.

ATWLPPR Peptide TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 118	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 177	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ATWLPPR Peptide TFA:

ATWLPPR Peptide Get quote

1 Publications Citing Use of MCE ATWLPPR Peptide TFA

•Sci Adv. 2020 Nov 25;6(48):eabc4493. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF₁₆₅ binding to NRP-1, used in the research of angiogenesis^[1]. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes^[2].

IC₅₀ & Target

Neuropilin-1^[2]

In Vitro

ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor, inhibits VEGF₁₆₅ binding to NRP-1 by 82% at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATWLPPR (400 μg/kg, s.c.) preserves vascular integrity and decreases the oxidative stress level, possibly reduces the early retinal damage caused by diabetes^[2].
ATWLPPR prevents the increase of inflammation-associated proteins (GFAP, VEGF and ICAM-1) in the retina^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

954.00

Formula

C₄₂H₆₂F₃N₁₁O₁₁

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)[C@H](C)N.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (104.82 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0482 mL	5.2411 mL	10.4822 mL
5 mM	0.2096 mL	1.0482 mL	2.0964 mL
10 mM	0.1048 mL	0.5241 mL	1.0482 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (104.82 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (284 KB) SDS (252 KB)

COA (263 KB) RP-HPLC (279 KB) MS (69 KB) Elemental Analysis Report (123 KB)

Handling Instructions (2659 KB)

References

[1]. Starzec A, et al. Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex. Peptides. 2007 Dec;28(12):2397-402. [Content Brief]

[2]. Wang J, et al. The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress. PLoS One. 2015 Nov 10;10(11):e0142571. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0482 mL	5.2411 mL	10.4822 mL	26.2055 mL
	5 mM	0.2096 mL	1.0482 mL	2.0964 mL	5.2411 mL
	10 mM	0.1048 mL	0.5241 mL	1.0482 mL	2.6205 mL
	15 mM	0.0699 mL	0.3494 mL	0.6988 mL	1.7470 mL
	20 mM	0.0524 mL	0.2621 mL	0.5241 mL	1.3103 mL
	25 mM	0.0419 mL	0.2096 mL	0.4193 mL	1.0482 mL
	30 mM	0.0349 mL	0.1747 mL	0.3494 mL	0.8735 mL
	40 mM	0.0262 mL	0.1310 mL	0.2621 mL	0.6551 mL
	50 mM	0.0210 mL	0.1048 mL	0.2096 mL	0.5241 mL
	60 mM	0.0175 mL	0.0874 mL	0.1747 mL	0.4368 mL
	80 mM	0.0131 mL	0.0655 mL	0.1310 mL	0.3276 mL
	100 mM	0.0105 mL	0.0524 mL	0.1048 mL	0.2621 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.