2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Amelubant

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Amelubant Chemical Structure

Amelubant Chemical Structure

CAS No. : 346735-24-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 569 In-stock
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10 mM * 1 mL in DMSO USD 569 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1550 In-stock
50 mg USD 2400 In-stock
100 mg USD 3600 In-stock
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Based on 1 publication(s) in Google Scholar

Amelubant Related Antibodies

Top Publications Citing Use of Products

View All Leukotriene Receptor Isoform Specific Products:

View All Isoforms
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • Biological Activity

  • Purity & Documentation

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Description

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1].

IC50 & Target[1]

LTB4

221 nM (Ki, in vital human granulocytes)

LTB4

230 nM (Ki, in cell membranes)

In Vitro

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amelubant Related Antibodies
Clinical Trial
Molecular Weight

538.63

Formula

C33H34N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(OCC2=CC(COC3=CC=C(C(NC(OCC)=O)=N)C=C3)=CC=C2)C=C1)(C4=CC=C(O)C=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (185.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8566 mL 9.2828 mL 18.5656 mL
5 mM 0.3713 mL 1.8566 mL 3.7131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8566 mL 9.2828 mL 18.5656 mL 46.4141 mL
5 mM 0.3713 mL 1.8566 mL 3.7131 mL 9.2828 mL
10 mM 0.1857 mL 0.9283 mL 1.8566 mL 4.6414 mL
15 mM 0.1238 mL 0.6189 mL 1.2377 mL 3.0943 mL
20 mM 0.0928 mL 0.4641 mL 0.9283 mL 2.3207 mL
25 mM 0.0743 mL 0.3713 mL 0.7426 mL 1.8566 mL
30 mM 0.0619 mL 0.3094 mL 0.6189 mL 1.5471 mL
40 mM 0.0464 mL 0.2321 mL 0.4641 mL 1.1604 mL
50 mM 0.0371 mL 0.1857 mL 0.3713 mL 0.9283 mL
60 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7736 mL
80 mM 0.0232 mL 0.1160 mL 0.2321 mL 0.5802 mL
100 mM 0.0186 mL 0.0928 mL 0.1857 mL 0.4641 mL
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Amelubant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amelubant346735-24-8BIIL 284BIIL284BIIL-284Leukotriene ReceptorInhibitorinhibitorinhibit

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