2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Membrane Transporter/Ion Channel Neuronal Signaling
  3. Endogenous Metabolite Reactive Oxygen Species Calcium Channel SOD NOD-like Receptor (NLR)
  4. Aminoadipic acid

Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research.

For research use only. We do not sell to patients.

Aminoadipic acid Chemical Structure

Aminoadipic acid Chemical Structure

CAS No. : 542-32-5

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Based on 2 publication(s) in Google Scholar

Other Forms of Aminoadipic acid:

Aminoadipic acid Related Antibodies

Top Publications Citing Use of Products

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Aminoadipic acid (1 μM-1 mM; 1 h) induces ROS generation and increases free Ca2+ and protein carbonyl levels in mouse pancreatic acinar cells[3].
Aminoadipic acid (419 ng/mL) induces inflammation by activating ROS/TXNIP/NLRP3 pathway in HUVEC cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminoadipic acid Related Antibodies
In Vivo

Aminoadipic acid (1%-2%; p.o., added to drinking water; ad libitum; 13 weeks) aggravates atherosclerotic vascular inflammation in atherosclerotic ApoE-/- mice fed a high-fat diet[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

161.16

Formula

C6H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N)CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 2.86 mg/mL (17.75 mM; Need ultrasonic)

DMSO : 2 mg/mL (12.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2050 mL 31.0251 mL 62.0501 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 4 mg/mL (24.82 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (243 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.2050 mL 31.0251 mL 62.0501 mL 155.1253 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL 31.0251 mL
10 mM 0.6205 mL 3.1025 mL 6.2050 mL 15.5125 mL
H2O 15 mM 0.4137 mL 2.0683 mL 4.1367 mL 10.3417 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Aminoadipic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminoadipic acid542-32-5Endogenous MetaboliteReactive Oxygen SpeciesCalcium ChannelSODNOD-like Receptor (NLR)Ca2+ channelsCa channelsSuperoxide DismutaseInhibitorinhibitorinhibit

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