2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Bilirubin

Bilirubin is a yellow breakdown product of heme catabolism. Bilirubin exhibits antioxidant and antimutagenic effects.

For research use only. We do not sell to patients.

Bilirubin Chemical Structure

Bilirubin Chemical Structure

CAS No. : 635-65-4

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Based on 3 publication(s) in Google Scholar

Bilirubin Related Antibodies

Top Publications Citing Use of Products
WB

    Bilirubin purchased from MedChemExpress. Usage Cited in: J Bone Oncol. 2023 Feb 23.

    Bilirubin (IBIL; 15 μM) markedly decreases the expression of MMP-2 and upregulates the expression of TIMP-2 in 143B and MG63 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bilirubin is a yellow breakdown product of heme catabolism[1]. Bilirubin exhibits antioxidant and antimutagenic effects[2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Unconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bilirubin Related Antibodies
    Clinical Trial
    Molecular Weight

    584.66

    Formula

    C33H36N4O6
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    CC(C(N/1)=O)=C(C=C)C1=C\C2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(/C=C4NC(C(C=C)=C\4C)=O)N3)N2
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 4 mg/mL (6.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    0.1 M HCL : < 1 mg/mL (insoluble)

    0.1 M NaOH : < 1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7104 mL 8.5520 mL 17.1040 mL
    5 mM 0.3421 mL 1.7104 mL 3.4208 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 10 mg/mL (17.10 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.71%

    COA (257 KB) HNMR (322 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7104 mL 8.5520 mL 17.1040 mL 42.7599 mL
    5 mM 0.3421 mL 1.7104 mL 3.4208 mL 8.5520 mL
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    Bilirubin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bilirubin635-65-4Endogenous MetabolitehemecatabolismantioxidantantimutagenicInhibitorinhibitorinhibit

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    Inquiry Information

    Product Name:
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    Cat. No.:
    HY-N0323
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