CGP 25454A

Cat. No.: HY-100454 Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

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CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research.

For research use only. We do not sell to patients.

CGP 25454A Chemical Structure

CAS No. : 104391-26-6

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research^[1].

In Vitro

CGP 25454A (0.5-10 μM, 15 min) elicits a reproducible and concentration-dependent increase of the release of both DA and ACh in rat striatal slices with an increase by 62±3% and 100±7% at 10 μM. CGP 25454A is 12.9 fold more potent at pre- than post-synaptic DA receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGP 25454A (10-100 mg/kg, i.p., 60 min) produces a marked, close-dependent increase in Spiperone binding in rat striatum^[1].
CGP 25454A (0.5-100 mg/kg, i.p., 10-60 min) exerts opposite effects with a slight behavioral stimulation at low doses and a clear-cut central depressant action in the higher dose range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Tif rats with Amphetamine-induced hyperactivity^[1]
Dosage:	0.5-100 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Did not modify ambulation but increased rearing at 2.5 and 10mg/kg, started to produce sedation at 30 mg/kg and sedation became strong at 100 mg/kg as rats were almost motionless and none of them were cataleptic.

Molecular Weight

346.25

Formula

C₁₅H₂₁Cl₂N₃O₂

CAS No.

104391-26-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 3.5 mg/mL (10.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8881 mL	14.4404 mL	28.8809 mL
5 mM	0.5776 mL	2.8881 mL	5.7762 mL
10 mM	0.2888 mL	1.4440 mL	2.8881 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Bischoff S et al. CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):230-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8881 mL	14.4404 mL	28.8809 mL	72.2022 mL
	5 mM	0.5776 mL	2.8881 mL	5.7762 mL	14.4404 mL
	10 mM	0.2888 mL	1.4440 mL	2.8881 mL	7.2202 mL

CGP 25454A Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 25454A104391-26-6Dopamine Receptormajor depressionpresynapticdopamine autoreceptorantagonistTif ratsInhibitorinhibitorinhibit

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