Camobucol (Synonyms: AGIX 4207)

Cat. No.: HY-14916 Purity: 99.52%: FAQs
Data Sheet SDS COA Handling Instructions

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Camobucol (AGIX 4207) is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

For research use only. We do not sell to patients.

Camobucol Chemical Structure

CAS No. : 216167-92-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 607	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 607	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 816	In-stock	Estimated Time of Arrival: December 31
20 mg	USD 1440	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

Camobucol (AGIX 4207) is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

In Vitro

Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

574.88

Formula

C₃₃H₅₀O₄S₂

CAS No.

216167-92-9

Appearance

Solid

Color

White to yellow

SMILES

CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OCC(O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (173.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7395 mL	8.6975 mL	17.3949 mL
5 mM	0.3479 mL	1.7395 mL	3.4790 mL
10 mM	0.1739 mL	0.8697 mL	1.7395 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (137 KB) RP-HPLC (167 KB) LCMS (355 KB)

Handling Instructions (2659 KB)

References

[1]. Kunsch C, et al. AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of an [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7395 mL	8.6975 mL	17.3949 mL	43.4873 mL
	5 mM	0.3479 mL	1.7395 mL	3.4790 mL	8.6975 mL
	10 mM	0.1739 mL	0.8697 mL	1.7395 mL	4.3487 mL
	15 mM	0.1160 mL	0.5798 mL	1.1597 mL	2.8992 mL
	20 mM	0.0870 mL	0.4349 mL	0.8697 mL	2.1744 mL
	25 mM	0.0696 mL	0.3479 mL	0.6958 mL	1.7395 mL
	30 mM	0.0580 mL	0.2899 mL	0.5798 mL	1.4496 mL
	40 mM	0.0435 mL	0.2174 mL	0.4349 mL	1.0872 mL
	50 mM	0.0348 mL	0.1739 mL	0.3479 mL	0.8697 mL
	60 mM	0.0290 mL	0.1450 mL	0.2899 mL	0.7248 mL
	80 mM	0.0217 mL	0.1087 mL	0.2174 mL	0.5436 mL
	100 mM	0.0174 mL	0.0870 mL	0.1739 mL	0.4349 mL

Camobucol Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camobucol216167-92-9AGIX 4207AGIX4207AGIX-4207OthersInhibitorinhibitorinhibit

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