2. Anti-infection
  3. Antibiotic Bacterial
  4. Carbenicillin disodium

Carbenicillin disodium  (Synonyms: Sodium carbenicillin)

Cat. No.: HY-B0525A Purity: 99.14%
SDS COA Handling Instructions

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Carbenicillin disodium (Sodium carbenicillin) is a broad-spectrum semi-synthetic penicillin antibiotic for gram-negative bacteria. Carbenicillin disodium can interfere the cell wall synthesis while displaying low toxicity to plant tissue.

For research use only. We do not sell to patients.

Carbenicillin disodium Chemical Structure

Carbenicillin disodium Chemical Structure

CAS No. : 4800-94-6

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Based on 4 publication(s) in Google Scholar

Other Forms of Carbenicillin disodium:

Carbenicillin disodium Related Antibodies

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  • Biological Activity

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Description

Carbenicillin disodium (Sodium carbenicillin) is a broad-spectrum semi-synthetic penicillin antibiotic for gram-negative bacteria. Carbenicillin disodium can interfere the cell wall synthesis while displaying low toxicity to plant tissue[1].

IC50 & Target

β-lactam

 

In Vivo

Carbenicillin (100-400 mg/kg; intramuscular injection every 8 h for 72 h) disodium significantly reduces mortality of neutropenic Pseudomonas-infected rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

422.36

Formula

C17H16N2Na2O6S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(C(O[Na])=O)C3=CC=CC=C3)=O)N1C2=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (295.96 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (147.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3676 mL 11.8382 mL 23.6765 mL
5 mM 0.4735 mL 2.3676 mL 4.7353 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (236.76 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.14%

SDS (419 KB)

COA (256 KB) HNMR (266 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3676 mL 11.8382 mL 23.6765 mL 59.1912 mL
5 mM 0.4735 mL 2.3676 mL 4.7353 mL 11.8382 mL
10 mM 0.2368 mL 1.1838 mL 2.3676 mL 5.9191 mL
15 mM 0.1578 mL 0.7892 mL 1.5784 mL 3.9461 mL
20 mM 0.1184 mL 0.5919 mL 1.1838 mL 2.9596 mL
25 mM 0.0947 mL 0.4735 mL 0.9471 mL 2.3676 mL
30 mM 0.0789 mL 0.3946 mL 0.7892 mL 1.9730 mL
40 mM 0.0592 mL 0.2960 mL 0.5919 mL 1.4798 mL
50 mM 0.0474 mL 0.2368 mL 0.4735 mL 1.1838 mL
60 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9865 mL
80 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7399 mL
100 mM 0.0237 mL 0.1184 mL 0.2368 mL 0.5919 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Carbenicillin disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbenicillin disodium4800-94-6Sodium carbenicillinAntibioticBacterialbroad-spectrumsemi-syntheticgram-negativeInhibitorinhibitorinhibit

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