2. Anti-infection Neuronal Signaling GPCR/G Protein
  3. Antibiotic Penicillin-binding protein (PBP) Bacterial 5-HT Receptor
  4. Cefaclor

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.

For research use only. We do not sell to patients.

Cefaclor Chemical Structure

Cefaclor Chemical Structure

CAS No. : 53994-73-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Cefaclor:

Cefaclor Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cefaclor

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections[1][2][3][4].

IC50 & Target

β-lactam

 

hOAT1

 

hPepT1-人肽转运蛋白 1

 

hPepT2-人肽转运蛋白 2

 

CD63

 

BDNF

 

5-HT Receptor

 

In Vitro

Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro[4].
Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1、hPepT1 and hPepT2[2].
Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefaclor Related Antibodies
In Vivo

Cefaclor (200 mg/kg/day, p.o. once a day for 5 days) can cause intestinal flora imbalance in mice, as well as anxiety and depression-like behaviors in mice. These symptoms can be alleviated by Fluoxetine (HY-B0102) or vagotomy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (male, 5 weeks old)[1]
Dosage: 200 mg/kg/day, once a day for 5 days.
Administration: p.o.
Result: Significantly decreased serotonin levels in the hippocampus and BDNF in mice.
Cefaclor-induced gut dysbiosis caused anxiety and depression through the microbiota-gut-blood-brain and the microbiota-gut-vagus nerve-brain pathway.
Clinical Trial
Molecular Weight

367.81

Formula

C15H14ClN3O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 18.5 mg/mL (50.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 3.85 mg/mL (10.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7188 mL 13.5940 mL 27.1880 mL
5 mM 0.5438 mL 2.7188 mL 5.4376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 3.33 mg/mL (9.05 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • Protocol 2

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 40 mg/mL (108.75 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.7188 mL 13.5940 mL 27.1880 mL 67.9699 mL
5 mM 0.5438 mL 2.7188 mL 5.4376 mL 13.5940 mL
10 mM 0.2719 mL 1.3594 mL 2.7188 mL 6.7970 mL
DMSO 15 mM 0.1813 mL 0.9063 mL 1.8125 mL 4.5313 mL
20 mM 0.1359 mL 0.6797 mL 1.3594 mL 3.3985 mL
25 mM 0.1088 mL 0.5438 mL 1.0875 mL 2.7188 mL
30 mM 0.0906 mL 0.4531 mL 0.9063 mL 2.2657 mL
40 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
50 mM 0.0544 mL 0.2719 mL 0.5438 mL 1.3594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cefaclor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefaclor53994-73-3AntibioticPenicillin-binding protein (PBP)Bacterial5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantibioticwell-absorbedoralpenicillin-binding protein 3 (PBP3)bacteriarespiratory tract infectionsbacterial bronchitispharyngitisskin infectionsInhibitorinhibitorinhibit

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