Cefamandole nafate (Synonyms: Cefamandole formate sodium)

Cat. No.: HY-B1166 Purity: 98.59%: FAQs
Data Sheet SDS COA Handling Instructions

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Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic.

For research use only. We do not sell to patients.

Cefamandole nafate Chemical Structure

CAS No. : 42540-40-9

Size	Price	Stock	Quantity
100 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 192	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Cefamandole nafate:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic^[1].

IC₅₀ & Target

β-lactam

In Vitro

Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month^[1].
After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.49

Formula

C₁₉H₁₇N₆NaO₆S₂

CAS No.

42540-40-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](OC=O)C4=CC=CC=C4)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (341.47 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9513 mL	9.7563 mL	19.5126 mL
5 mM	0.3903 mL	1.9513 mL	3.9025 mL
10 mM	0.1951 mL	0.9756 mL	1.9513 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (195.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.59%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. J S Wold, et al. Toxicologic evaluation of cefamandole nafate in laboratory animals. J Infect Dis. 1978 May;137 Suppl:S51-S59. [Content Brief]

[2]. J R Turner, et al. Delineation of the relative antibacterial activity of cefamandole and cefamandole nafate. Antimicrob Agents Chemother. 1977 Jul;12(1):67-72. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9513 mL	9.7563 mL	19.5126 mL	48.7814 mL
	5 mM	0.3903 mL	1.9513 mL	3.9025 mL	9.7563 mL
	10 mM	0.1951 mL	0.9756 mL	1.9513 mL	4.8781 mL
	15 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2521 mL
	20 mM	0.0976 mL	0.4878 mL	0.9756 mL	2.4391 mL
	25 mM	0.0781 mL	0.3903 mL	0.7805 mL	1.9513 mL
	30 mM	0.0650 mL	0.3252 mL	0.6504 mL	1.6260 mL
	40 mM	0.0488 mL	0.2439 mL	0.4878 mL	1.2195 mL
	50 mM	0.0390 mL	0.1951 mL	0.3903 mL	0.9756 mL
	60 mM	0.0325 mL	0.1626 mL	0.3252 mL	0.8130 mL
	80 mM	0.0244 mL	0.1220 mL	0.2439 mL	0.6098 mL
	100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.4878 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cefamandole nafate Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefamandole nafate42540-40-9Cefamandole formateBacterialAntibioticInhibitorinhibitorinhibit

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