2. Anti-infection
  3. Antibiotic Bacterial
  4. Cefmenoxime hydrochloride

Cefmenoxime hydrochloride  (Synonyms: SCE-1365 hydrochloride)

Cat. No.: HY-B0875 Purity: 99.29%
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Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Cefmenoxime hydrochloride Chemical Structure

Cefmenoxime hydrochloride Chemical Structure

CAS No. : 75738-58-8

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Cefmenoxime hydrochloride:

Cefmenoxime hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1].
Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1].
Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefmenoxime hydrochloride Related Antibodies
In Vivo

Cefmenoxime (SCE-1365) hydrochloride (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Jcl:ICR mice[2]
Dosage: 40 mg/kg
Administration: Subcutaneous injection; daily, for 7 days
Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
Molecular Weight

529.79

Formula

C16H17.5Cl0.5N9O5S3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O.[0.5HCl]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 65 mg/mL (122.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8875 mL 9.4377 mL 18.8754 mL
5 mM 0.3775 mL 1.8875 mL 3.7751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.29%

COA (255 KB) HNMR (282 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8875 mL 9.4377 mL 18.8754 mL 47.1885 mL
5 mM 0.3775 mL 1.8875 mL 3.7751 mL 9.4377 mL
10 mM 0.1888 mL 0.9438 mL 1.8875 mL 4.7189 mL
15 mM 0.1258 mL 0.6292 mL 1.2584 mL 3.1459 mL
20 mM 0.0944 mL 0.4719 mL 0.9438 mL 2.3594 mL
25 mM 0.0755 mL 0.3775 mL 0.7550 mL 1.8875 mL
30 mM 0.0629 mL 0.3146 mL 0.6292 mL 1.5730 mL
40 mM 0.0472 mL 0.2359 mL 0.4719 mL 1.1797 mL
50 mM 0.0378 mL 0.1888 mL 0.3775 mL 0.9438 mL
60 mM 0.0315 mL 0.1573 mL 0.3146 mL 0.7865 mL
80 mM 0.0236 mL 0.1180 mL 0.2359 mL 0.5899 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4719 mL
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Cefmenoxime hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefmenoxime75738-58-8SCE-1365SCE1365SCE 1365AntibioticBacterialCephalosporinantibacterialgram-positivegram-negativeInhibitorinhibitorinhibit

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