Dansyl glutathione (Synonyms: DNS-glutathione)

Name: Dansyl glutathione
Brand: MedChemExpress
SKU: HY-101131
Rating: 4.5 (1 reviews)

Cat. No.: HY-101131 Purity: 99.33%: FAQs
Data Sheet SDS COA Handling Instructions

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Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.

For research use only. We do not sell to patients.

Dansyl glutathione Chemical Structure

CAS No. : 75017-02-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 357	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 357	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.

In Vitro

Dansyl glutathione is used as a trapping agent to aid the quantitation of adducts following in vitro incubation of drugs with human liver microsomes in the presence and absence of NADPH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

540.61

Formula

C₂₂H₂₈N₄O₈S₂

CAS No.

75017-02-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(N[C@@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (184.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (92.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8498 mL	9.2488 mL	18.4976 mL
5 mM	0.3700 mL	1.8498 mL	3.6995 mL
10 mM	0.1850 mL	0.9249 mL	1.8498 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Gan J, et al. In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation. Chem Res Toxicol. 2009 Apr;22(4):690-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8498 mL	9.2488 mL	18.4976 mL	46.2441 mL
	5 mM	0.3700 mL	1.8498 mL	3.6995 mL	9.2488 mL
	10 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6244 mL
	15 mM	0.1233 mL	0.6166 mL	1.2332 mL	3.0829 mL
	20 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	25 mM	0.0740 mL	0.3700 mL	0.7399 mL	1.8498 mL
	30 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5415 mL
	40 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1561 mL
	50 mM	0.0370 mL	0.1850 mL	0.3700 mL	0.9249 mL
	60 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL
	80 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5781 mL
DMSO	100 mM	0.0185 mL	0.0925 mL	0.1850 mL	0.4624 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Dansyl glutathione Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dansyl glutathione75017-02-6DNS-glutathioneOthersInhibitorinhibitorinhibit

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Dansyl glutathione (Synonyms: DNS-glutathione)

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Dansyl glutathione Related Antibodies

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Complete Stock Solution Preparation Table

Dansyl glutathione Related Classifications

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