2. Anti-infection
  3. Parasite
  4. Dinitolmide

Dinitolmide  (Synonyms: Zoalene)

Cat. No.: HY-B1004 Purity: 99.66%
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Dinitolmide (Zoalene), a fodder additive for poultry, has anti-coccidial effect. Dinitolmide can be used to prevent infections induced by Eimeria, such as Eimeria tenella, Eimeria necatrix, Eimeria brunette, and so on.

For research use only. We do not sell to patients.

Dinitolmide Chemical Structure

Dinitolmide Chemical Structure

CAS No. : 148-01-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 42 In-stock
Solution
10 mM * 1 mL in DMSO USD 42 In-stock
Solid
25 mg USD 39 In-stock
50 mg USD 60 In-stock
100 mg USD 95 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Dinitolmide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dinitolmide

IF

    Dinitolmide purchased from MedChemExpress. Usage Cited in: Vet Parasitol. 2023 Mar 2;316:109903.  [Abstract]

    Dinitolmide (10 µg/mL; 15 h) corrupts the integrity of the T. gondii membrane, while has no significant impact to the mitochondria structure.

    View All Parasite Isoform Specific Products:

    View All Isoforms
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Dinitolmide (Zoalene), a fodder additive for poultry, has anti-coccidial effect. Dinitolmide can be used to prevent infections induced by Eimeria, such as Eimeria tenella, Eimeria necatrix, Eimeria brunette, and so on[1].

    IC50 & Target

    Coccidia

     

    Molecular Weight

    225.16

    Formula

    C8H7N3O5
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(N)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (444.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.4413 mL 22.2064 mL 44.4129 mL
    5 mM 0.8883 mL 4.4413 mL 8.8826 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (11.10 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (11.10 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.4413 mL 22.2064 mL 44.4129 mL 111.0322 mL
    5 mM 0.8883 mL 4.4413 mL 8.8826 mL 22.2064 mL
    10 mM 0.4441 mL 2.2206 mL 4.4413 mL 11.1032 mL
    15 mM 0.2961 mL 1.4804 mL 2.9609 mL 7.4021 mL
    20 mM 0.2221 mL 1.1103 mL 2.2206 mL 5.5516 mL
    25 mM 0.1777 mL 0.8883 mL 1.7765 mL 4.4413 mL
    30 mM 0.1480 mL 0.7402 mL 1.4804 mL 3.7011 mL
    40 mM 0.1110 mL 0.5552 mL 1.1103 mL 2.7758 mL
    50 mM 0.0888 mL 0.4441 mL 0.8883 mL 2.2206 mL
    60 mM 0.0740 mL 0.3701 mL 0.7402 mL 1.8505 mL
    80 mM 0.0555 mL 0.2776 mL 0.5552 mL 1.3879 mL
    100 mM 0.0444 mL 0.2221 mL 0.4441 mL 1.1103 mL
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    Dinitolmide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dinitolmide148-01-6ZoaleneParasiteInhibitorinhibitorinhibit

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