Docosapentaenoic acid (22n-3) (Synonyms: Clupanodonic acid)

Cat. No.: HY-113159 Purity: 99.87%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect.

For research use only. We do not sell to patients.

Docosapentaenoic acid (22n-3) Chemical Structure

CAS No. : 24880-45-3

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of Docosapentaenoic acid (22n-3):

Docosapentaenoic acid (22n-3) sodium Get quote

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Description

IC₅₀ & Target

IC₅₀: 17 μg/mL (α-amylase)

In Vitro

Docosapentaenoic acid 22n-3 (50-100 μM; 24 h) increases vitality of bone marrow-derived stem cells (BMSCs)^[2].
Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively^[3].
Docosapentaenoic acid 22n-3 (16 μg/mL) has a weaker anti-inflammatory effect than Phenylalanine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

330.50

Formula

C₂₂H₃₄O₂

CAS No.

24880-45-3

Appearance

Liquid (Density: 0.932±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (151.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0257 mL	15.1286 mL	30.2572 mL
5 mM	0.6051 mL	3.0257 mL	6.0514 mL
10 mM	0.3026 mL	1.5129 mL	3.0257 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.56 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.56 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (237 KB) HNMR (211 KB) RP-HPLC (227 KB)

Handling Instructions (2659 KB)

References

[1]. Sinclair HM, et al. Essential fatty acids in perspective. Hum Nutr Clin Nutr. 1984 Jul;38(4):245-60. [Content Brief]

[2]. Peng H, et al. Cartilaginous Metabolomics Reveals the Biochemical-Niche Fate Control of Bone Marrow-Derived Stem Cells. Cells. 2022 Sep 21;11(19):2951. [Content Brief]

[3]. Sivaramakrishnan R, et al. In vitro anti-diabetic and anti-inflammatory activities of metabolites isolated from Marine Sponge, Heteronema erecta (Keller, 1889) and its in silico studies[J]. Research Journal of Biotechnology Vol, 2020, 15: 12.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0257 mL	15.1286 mL	30.2572 mL	75.6430 mL
	5 mM	0.6051 mL	3.0257 mL	6.0514 mL	15.1286 mL
	10 mM	0.3026 mL	1.5129 mL	3.0257 mL	7.5643 mL
	15 mM	0.2017 mL	1.0086 mL	2.0171 mL	5.0429 mL
	20 mM	0.1513 mL	0.7564 mL	1.5129 mL	3.7821 mL
	25 mM	0.1210 mL	0.6051 mL	1.2103 mL	3.0257 mL
	30 mM	0.1009 mL	0.5043 mL	1.0086 mL	2.5214 mL
	40 mM	0.0756 mL	0.3782 mL	0.7564 mL	1.8911 mL
	50 mM	0.0605 mL	0.3026 mL	0.6051 mL	1.5129 mL
	60 mM	0.0504 mL	0.2521 mL	0.5043 mL	1.2607 mL
	80 mM	0.0378 mL	0.1891 mL	0.3782 mL	0.9455 mL
	100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7564 mL

Docosapentaenoic acid (22n-3) Related Classifications

Metabolic Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Docosapentaenoic acid (22n-3)24880-45-3Clupanodonic acidAmylasesGlycosidaseBMSCsanti-inflammatoryInhibitorinhibitorinhibit

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Docosapentaenoic acid (22n-3) (Synonyms: Clupanodonic acid)

Other Forms of Docosapentaenoic acid (22n-3):

Docosapentaenoic acid (22n-3) Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Docosapentaenoic acid (22n-3) Related Antibodies

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