Doxifluridine (Synonyms: Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR)

Name: Doxifluridine
Brand: MedChemExpress
SKU: HY-B0021
Rating: 5.0 (2 reviews)

Cat. No.: HY-B0021 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs.

For research use only. We do not sell to patients.

Doxifluridine Chemical Structure

CAS No. : 3094-09-5

Size	Price	Stock	Quantity

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
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500 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Doxifluridine:

2 Publications Citing Use of MCE Doxifluridine

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•Related Screening Libraries:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Doxifluridine (1-10 μM) inhibits angiogenesis by significantly inhibiting the expression of VEGF in FU-MMT-1 cells^[1].
Doxifluridine (1-100 μM) slightly increases the expression of TSP-1 at low dose (1 μM) and inhibits the expression of TSP-1 at high dose (100 μM) in FU-MMT-1 cells^[1].
Doxifluridine (100 μM) inhibits cell proliferation in HUVEC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Doxifluridine (61.55 mg/kg; Intragastric administration; Single dose) has anticancer activity in BALB ⁄ cA Jcl-nu mice, and can significantly enhance anticancer activity in combination with TNP-470 (HY-101932)^[1].
Doxifluridine (200 mg/kg; Intraperitoneal injection; Single dose) can inhibit thymidine synthase activity in DMH-induced colon cancer mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

246.19

Formula

C₉H₁₁FN₂O₅

CAS No.

3094-09-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)N([C@H]2[C@H](O)[C@H](O)[C@@H](C)O2)C=C(F)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (406.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 100 mg/mL (406.19 mM; Need ultrasonic)

H₂O : 20 mg/mL (81.24 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0619 mL	20.3095 mL	40.6190 mL
5 mM	0.8124 mL	4.0619 mL	8.1238 mL
10 mM	0.4062 mL	2.0310 mL	4.0619 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 27.5 mg/mL (111.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (277 KB) SDS (253 KB)

COA (252 KB) LCMS (273 KB)

Handling Instructions (2659 KB)

References

[1]. Naganuma Y, et al. Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. Cancer Sci. 2011 Aug;102(8):1545-52. [Content Brief]

[2]. Berne M, et al. Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Cancer Invest. 1988;6(4):377-83. [Content Brief]

[3]. Di Bartolomeo M, et al. Integrated treatment with doxifluridine and radiotherapy in recurrent or primary unresectable rectal cancer. A feasibility study. Tumori. 1999 May-Jun;85(3):211-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO / DMF	1 mM	4.0619 mL	20.3095 mL	40.6190 mL	101.5476 mL
	5 mM	0.8124 mL	4.0619 mL	8.1238 mL	20.3095 mL
	10 mM	0.4062 mL	2.0310 mL	4.0619 mL	10.1548 mL
	15 mM	0.2708 mL	1.3540 mL	2.7079 mL	6.7698 mL
	20 mM	0.2031 mL	1.0155 mL	2.0310 mL	5.0774 mL
	25 mM	0.1625 mL	0.8124 mL	1.6248 mL	4.0619 mL
	30 mM	0.1354 mL	0.6770 mL	1.3540 mL	3.3849 mL
	40 mM	0.1015 mL	0.5077 mL	1.0155 mL	2.5387 mL
	50 mM	0.0812 mL	0.4062 mL	0.8124 mL	2.0310 mL
	60 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6925 mL
	80 mM	0.0508 mL	0.2539 mL	0.5077 mL	1.2693 mL
DMSO / DMF	100 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0155 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Doxifluridine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxifluridine3094-09-5Ro 21-9738 5-Fluoro-5'-deoxyuridine 5'-DFURThymidylate SynthaseCervical cancercolon cancer5-FU5-dFURBALB ? cA Jcl-nuFU-MMT-1Inhibitorinhibitorinhibit

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Doxifluridine (Synonyms: Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR)

Customer Review

Other Forms of Doxifluridine:

Doxifluridine Related Antibodies

2 Publications Citing Use of MCE Doxifluridine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Doxifluridine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Doxifluridine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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