2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG4-Ph-NH2

Pomalidomide-PEG4-Ph-NH2  (Synonyms: Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2)

Cat. No.: HY-41549 Purity: ≥98.0%
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Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG4-Ph-NH2 Chemical Structure

Pomalidomide-PEG4-Ph-NH2 Chemical Structure

CAS No. : 1818885-63-0

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Based on 1 publication(s) in Google Scholar

Pomalidomide-PEG4-Ph-NH2 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

540.57

Formula

C27H32N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOC4=CC=C(N)C=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (92.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8499 mL 9.2495 mL 18.4990 mL
5 mM 0.3700 mL 1.8499 mL 3.6998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8499 mL 9.2495 mL 18.4990 mL 46.2475 mL
5 mM 0.3700 mL 1.8499 mL 3.6998 mL 9.2495 mL
10 mM 0.1850 mL 0.9249 mL 1.8499 mL 4.6247 mL
15 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
20 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3124 mL
25 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
30 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
40 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
50 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9249 mL
60 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
80 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
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Pomalidomide-PEG4-Ph-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG4-Ph-NH21818885-63-0Cereblon Ligand-Linker Conjugates 9 E3 Ligase Ligand-Linker Conjugates 2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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