Thalidomide-O-amido-C6-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 11 TFA; E3 Ligase Ligand-Linker Conjugates 25 TFA)

Name: Thalidomide-O-amido-C6-NH2 TFA
Brand: MedChemExpress
SKU: HY-112618A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112618A Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

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Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C6-NH2 TFA Chemical Structure

CAS No. : 1950635-14-9

Size	Price	Stock	Quantity
50 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 527	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1869	In-stock	Estimated Time of Arrival: December 31
1 g	USD 3210	In-stock	Estimated Time of Arrival: December 31
2 g	USD 4696	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-O-amido-C6-NH2 TFA:

Thalidomide-O-amido-C6-NH2 Get quote
Thalidomide-O-amido-C6-NH2 hydrochloride Get quote

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Biological Activity
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References
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Description

IC₅₀ & Target^[1]

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

544.48

Formula

C₂₃H₂₇F₃N₄O₈

CAS No.

1950635-14-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (183.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8366 mL	9.1831 mL	18.3661 mL
5 mM	0.3673 mL	1.8366 mL	3.6732 mL
10 mM	0.1837 mL	0.9183 mL	1.8366 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8366 mL	9.1831 mL	18.3661 mL	45.9154 mL
	5 mM	0.3673 mL	1.8366 mL	3.6732 mL	9.1831 mL
	10 mM	0.1837 mL	0.9183 mL	1.8366 mL	4.5915 mL
	15 mM	0.1224 mL	0.6122 mL	1.2244 mL	3.0610 mL
	20 mM	0.0918 mL	0.4592 mL	0.9183 mL	2.2958 mL
	25 mM	0.0735 mL	0.3673 mL	0.7346 mL	1.8366 mL
	30 mM	0.0612 mL	0.3061 mL	0.6122 mL	1.5305 mL
	40 mM	0.0459 mL	0.2296 mL	0.4592 mL	1.1479 mL
	50 mM	0.0367 mL	0.1837 mL	0.3673 mL	0.9183 mL
	60 mM	0.0306 mL	0.1531 mL	0.3061 mL	0.7653 mL
	80 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5739 mL
	100 mM	0.0184 mL	0.0918 mL	0.1837 mL	0.4592 mL

Thalidomide-O-amido-C6-NH2 TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-C6-NH21950635-14-9Cereblon Ligand-Linker Conjugates 11E3 Ligase Ligand-Linker Conjugates 25E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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Thalidomide-O-amido-C6-NH2 TFA (Synonyms: Cereblon Ligand-Linker Conjugates 11 TFA; E3 Ligase Ligand-Linker Conjugates 25 TFA)

Customer Review

Other Forms of Thalidomide-O-amido-C6-NH2 TFA:

Thalidomide-O-amido-C6-NH2 TFA Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Thalidomide-O-amido-C6-NH2 TFA Related Antibodies

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Complete Stock Solution Preparation Table

Thalidomide-O-amido-C6-NH2 TFA Related Classifications

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