2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG4-N3

(S,R,S)-AHPC-PEG4-N3  (Synonyms: VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4)

Cat. No.: HY-103601 Purity: 99.93%
SDS COA Handling Instructions

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(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG4-N3 Chemical Structure

(S,R,S)-AHPC-PEG4-N3 Chemical Structure

CAS No. : 1797406-81-5

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25 mg USD 190 In-stock
50 mg USD 310 In-stock
100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG4-N3 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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  • Purity & Documentation

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Description

(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target[1]

VHL

 

In Vitro

E3?ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG4-N3 Related Antibodies
Molecular Weight

689.82

Formula

C32H47N7O8S
CAS No.
Appearance

Liquid

Color

Colorless to off-white

SMILES

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (144.97 mM; Need ultrasonic)

DMSO : 50 mg/mL (72.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4497 mL 7.2483 mL 14.4965 mL
5 mM 0.2899 mL 1.4497 mL 2.8993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.93%

SDS (393 KB)

COA (249 KB) HNMR (283 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.4497 mL 7.2483 mL 14.4965 mL 36.2413 mL
5 mM 0.2899 mL 1.4497 mL 2.8993 mL 7.2483 mL
10 mM 0.1450 mL 0.7248 mL 1.4497 mL 3.6241 mL
15 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4161 mL
20 mM 0.0725 mL 0.3624 mL 0.7248 mL 1.8121 mL
25 mM 0.0580 mL 0.2899 mL 0.5799 mL 1.4497 mL
30 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
40 mM 0.0362 mL 0.1812 mL 0.3624 mL 0.9060 mL
50 mM 0.0290 mL 0.1450 mL 0.2899 mL 0.7248 mL
60 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6040 mL
H2O 80 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.4530 mL
100 mM 0.0145 mL 0.0725 mL 0.1450 mL 0.3624 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-PEG4-N3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG4-N31797406-81-5VH032-PEG4-N3 VHL Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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