2. Metabolic Enzyme/Protease Apoptosis
  3. Angiotensin-converting Enzyme (ACE) Apoptosis
  4. Fosinopril sodium

Fosinopril sodium  (Synonyms: SQ28555)

Cat. No.: HY-B0382 Purity: 99.89%
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Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

For research use only. We do not sell to patients.

Fosinopril sodium Chemical Structure

Fosinopril sodium Chemical Structure

CAS No. : 88889-14-9

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fosinopril sodium:

Fosinopril sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fosinopril sodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

IC50 & Target

IC50: 0.18 μM; Ki: 1.675 μM
In Vitro

Fosinopril (0, 1, 10, 33, 100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2[1].
Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2[1].
Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fosinopril sodium Related Antibodies
In Vivo

Fosinopril (orally; 4.67 mg/kg; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and against cardiac dysfunction and structural alteration[3].
Fosinopril (orally; 4.67 mg/kg; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HF post-acute myocardial infarction (AMI) rat model (SPF-grade Sprague-Dawley (SD) rats, 265 ± 15 g) [3]
Dosage: 4.67 mg/kg
Administration: p.o.; 4 weeks
Result: Against cardiac dysfunction and structural alteration and suppressed apoptosis.
Clinical Trial
Molecular Weight

585.64

Formula

C30H45NNaO7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@H]1N(C(C[P@@](CCCCC2=CC=CC=C2)(O[C@H](OC(CC)=O)C(C)C)=O)=O)C[C@H](C3CCCCC3)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (42.69 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 16.67 mg/mL (28.46 mM; Need ultrasonic)

DMSO : 1.43 mg/mL (2.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7075 mL 8.5377 mL 17.0753 mL
5 mM 0.3415 mL 1.7075 mL 3.4151 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 9.09 mg/mL (15.52 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol / H2O 1 mM 1.7075 mL 8.5377 mL 17.0753 mL 42.6883 mL
Ethanol / H2O 5 mM 0.3415 mL 1.7075 mL 3.4151 mL 8.5377 mL
10 mM 0.1708 mL 0.8538 mL 1.7075 mL 4.2688 mL
15 mM 0.1138 mL 0.5692 mL 1.1384 mL 2.8459 mL
20 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1344 mL
25 mM 0.0683 mL 0.3415 mL 0.6830 mL 1.7075 mL
H2O 30 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.4229 mL
40 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fosinopril sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosinopril88889-14-9SQ28555SQ 28555SQ-28555Angiotensin-converting Enzyme (ACE)Apoptosisangiotensin-converting enzymeACEanti-hypertensionInhibitorinhibitorinhibit

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