2. Protein Tyrosine Kinase/RTK
  3. Src
  4. KB SRC 4

KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

For research use only. We do not sell to patients.

KB SRC 4 Chemical Structure

KB SRC 4 Chemical Structure

CAS No. : 1380088-03-8

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 269 In-stock
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Based on 1 publication(s) in Google Scholar

KB SRC 4 Related Antibodies

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Lck Fyn Blk

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Description

KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

IC50 & Target

Ki: 44 nM (c-Src)[1]
Kd: 86 nM (c-Src)[1]
Cellular Effect
Cell Line Type Value Description References
HMEC GI50
4.3 μM
Compound: 1
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
[PMID: 24015327]
SK-BR-3 GI50
4.8 μM
Compound: 1
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
[PMID: 24015327]
In Vitro

KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KB SRC 4 Related Antibodies
Molecular Weight

555.03

Formula

C32H23ClN8
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (180.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8017 mL 9.0085 mL 18.0170 mL
5 mM 0.3603 mL 1.8017 mL 3.6034 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8017 mL 9.0085 mL 18.0170 mL 45.0426 mL
5 mM 0.3603 mL 1.8017 mL 3.6034 mL 9.0085 mL
10 mM 0.1802 mL 0.9009 mL 1.8017 mL 4.5043 mL
15 mM 0.1201 mL 0.6006 mL 1.2011 mL 3.0028 mL
20 mM 0.0901 mL 0.4504 mL 0.9009 mL 2.2521 mL
25 mM 0.0721 mL 0.3603 mL 0.7207 mL 1.8017 mL
30 mM 0.0601 mL 0.3003 mL 0.6006 mL 1.5014 mL
40 mM 0.0450 mL 0.2252 mL 0.4504 mL 1.1261 mL
50 mM 0.0360 mL 0.1802 mL 0.3603 mL 0.9009 mL
60 mM 0.0300 mL 0.1501 mL 0.3003 mL 0.7507 mL
80 mM 0.0225 mL 0.1126 mL 0.2252 mL 0.5630 mL
100 mM 0.0180 mL 0.0901 mL 0.1802 mL 0.4504 mL
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KB SRC 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KB SRC 41380088-03-8KB SRC4KB SRC-4SrcInhibitorinhibitorinhibit

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