Lathyrol

Cat. No.: HY-N0561 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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Lathyrol is a natural product, and is used for cancer treatment.

For research use only. We do not sell to patients.

Lathyrol Chemical Structure

CAS No. : 34420-19-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 155	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of Lathyrol:

Lathyrol (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Lathyrol is a natural product, and is used for cancer treatment.

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	34.04 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB colorimetric assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB colorimetric assay	[PMID: 25856545]
NCI/ADR-RES	EC₅₀	11.63 μM Compound: 2	Inhibition of P-gp in human MCF7/ADR cells assessed as reversal of multidrug resistance at 10 uM by measuring EC50 for adriamycin-induced cytotoxicity after 48 hrs by SRB colorimetric assay Inhibition of P-gp in human MCF7/ADR cells assessed as reversal of multidrug resistance at 10 uM by measuring EC50 for adriamycin-induced cytotoxicity after 48 hrs by SRB colorimetric assay	[PMID: 25856545]
NCI/ADR-RES	IC₅₀	59.56 μM Compound: 2	Cytotoxicity against human MCF7/ADR cells assessed as reduction in cell viability after 48 hrs by SRB colorimetric assay Cytotoxicity against human MCF7/ADR cells assessed as reduction in cell viability after 48 hrs by SRB colorimetric assay	[PMID: 25856545]
RAW264.7	IC₅₀	11.1 μM Compound: Lathyrol	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 35063896]
RAW264.7	IC₅₀	11.1 μM Compound: Lathyrol	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 3 hrs followed by LPS addition and measured after 24 hrs Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 3 hrs followed by LPS addition and measured after 24 hrs	[PMID: 37002536]

In Vitro

Lathyrol exhibits reversal effects in MCF-7/ADR breast cancer cell lines in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.45

Formula

C₂₀H₃₀O₄

CAS No.

34420-19-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(C(/C(C)=C\[C@@H](C2(C)C)[C@@H]2CCC3=C)=O)[C@]([C@H]3O)([H])[C@@H](O)[C@@H](C)C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (299.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9900 mL	14.9499 mL	29.8998 mL
5 mM	0.5980 mL	2.9900 mL	5.9800 mL
10 mM	0.2990 mL	1.4950 mL	2.9900 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (293 KB) SDS (251 KB)

COA (254 KB) HNMR (270 KB) RP-HPLC (246 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Jiao W, et al. Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives. J Med Chem. 2015 May 14;58(9):3720-38 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9900 mL	14.9499 mL	29.8998 mL	74.7496 mL
	5 mM	0.5980 mL	2.9900 mL	5.9800 mL	14.9499 mL
	10 mM	0.2990 mL	1.4950 mL	2.9900 mL	7.4750 mL
	15 mM	0.1993 mL	0.9967 mL	1.9933 mL	4.9833 mL
	20 mM	0.1495 mL	0.7475 mL	1.4950 mL	3.7375 mL
	25 mM	0.1196 mL	0.5980 mL	1.1960 mL	2.9900 mL
	30 mM	0.0997 mL	0.4983 mL	0.9967 mL	2.4917 mL
	40 mM	0.0747 mL	0.3737 mL	0.7475 mL	1.8687 mL
	50 mM	0.0598 mL	0.2990 mL	0.5980 mL	1.4950 mL
	60 mM	0.0498 mL	0.2492 mL	0.4983 mL	1.2458 mL
	80 mM	0.0374 mL	0.1869 mL	0.3737 mL	0.9344 mL
	100 mM	0.0299 mL	0.1495 mL	0.2990 mL	0.7475 mL

Lathyrol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lathyrol34420-19-4OthersInhibitorinhibitorinhibit

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