Licochalcone A (Synonyms: Licochalcone-A)

Name: Licochalcone A
Brand: MedChemExpress
SKU: HY-N0372
Rating: 5.0 (11 reviews)

Cat. No.: HY-N0372 Purity: 99.89%: FAQs
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Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs). Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

For research use only. We do not sell to patients.

Licochalcone A Chemical Structure

CAS No. : 58749-22-7

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Based on 11 publication(s) in Google Scholar

Other Forms of Licochalcone A:

Licochalcone A (Standard) Get quote

11 Publications Citing Use of MCE Licochalcone A

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Description

Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs)^[1]. Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) ^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	508.3 μM Compound: 118	Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay	[PMID: 33479649]
HEK293	IC₅₀	0.28 nM Compound: Licochalcone A	Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM) Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)	[PMID: 32347726]
HEK293	IC₅₀	0.3 nM Compound: Licochalcone A	Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM) Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)	[PMID: 32347726]
HEK293	IC₅₀	0.3 nM Compound: Licochalcone A	Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM) Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)	[PMID: 32347726]
HEK293	IC₅₀	0.31 nM Compound: Licochalcone A	Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM) Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)	[PMID: 32347726]
HEK293	IC₅₀	10 μM Compound: Licochalcone A	Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay	[PMID: 32347726]
HEK293	IC₅₀	10 μM Compound: Licochalcone A	Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay	[PMID: 32347726]
HEK293	IC₅₀	24.72 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM) Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)	[PMID: 32347726]
HEK293	IC₅₀	25.55 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM) Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)	[PMID: 32347726]
HEK293	IC₅₀	25.89 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM) Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)	[PMID: 32347726]
HEK293	IC₅₀	26.83 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM) Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)	[PMID: 32347726]
HEK293	IC₅₀	4.6 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM) Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)	[PMID: 32347726]
HEK293	IC₅₀	4.74 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM) Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)	[PMID: 32347726]
HEK293	IC₅₀	4.78 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM) Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)	[PMID: 32347726]
HEK293	IC₅₀	5.11 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM) Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)	[PMID: 32347726]
HEK293	IC₅₀	7.99 nM Compound: Licochalcone A	Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM) Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)	[PMID: 32347726]
HEK293	IC₅₀	8.67 nM Compound: Licochalcone A	Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM) Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)	[PMID: 32347726]
HEK293	IC₅₀	8.9 nM Compound: Licochalcone A	Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM) Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)	[PMID: 32347726]
HEK293	IC₅₀	9.03 nM Compound: Licochalcone A	Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM) Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)	[PMID: 32347726]
HEK-293T	IC₅₀	4.2 μg/mL Compound: 2	Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry	[PMID: 21123068]
HEK-293T	IC₅₀	5.42 μg/mL Compound: 2	Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry	[PMID: 21123068]
HeLa	IC₅₀	48.5 μM Compound: 4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31539776]
Hepatocyte	IC₅₀	0.927 nM Compound: Licochalcone A	Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs	[PMID: 18212104]
HK-2	IC₅₀	88.7 μM Compound: 4	Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay	[PMID: 31539776]
HT-1080	IC₅₀	10.75 μM Compound: Licochalcone A	Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs	[PMID: 31836442]
MCF7	IC₅₀	22 μM Compound: 4	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay	[PMID: 31539776]
MDA-MB-231	IC₅₀	22 μM Compound: 4	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay	[PMID: 31539776]
MSTO-211H	IC₅₀	26 μM Compound: 4	Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay	[PMID: 31539776]
NCI-H28	IC₅₀	30 μM Compound: 4	Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay	[PMID: 31539776]
NCI-H460	IC₅₀	10 μM Compound: Licochalcone A	Cytotoxicity against human H460 cells after 72 hrs by MTT assay Cytotoxicity against human H460 cells after 72 hrs by MTT assay	[PMID: 32347726]
NCI-H460	IC₅₀	19.84 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM) Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	20.1 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM) Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	20.34 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM) Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	21.69 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM) Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	22.41 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM) Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	22.52 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM) Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	25.54 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM) Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)	[PMID: 32347726]
NCI-H460	IC₅₀	25.91 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM) Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)	[PMID: 32347726]
S1	IC₅₀	10 μM Compound: Licochalcone A	Cytotoxicity against human S1 cells after 72 hrs by MTT assay Cytotoxicity against human S1 cells after 72 hrs by MTT assay	[PMID: 32347726]
S1	IC₅₀	10.7 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM) Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)	[PMID: 32347726]
S1	IC₅₀	11.01 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM) Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)	[PMID: 32347726]
S1	IC₅₀	11.74 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM) Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)	[PMID: 32347726]
S1	IC₅₀	4.44 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM) Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM)	[PMID: 32347726]
S1	IC₅₀	4.53 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM) Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)	[PMID: 32347726]
S1	IC₅₀	4.55 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM) Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)	[PMID: 32347726]
S1	IC₅₀	4.73 nM Compound: Licochalcone A	Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM) Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)	[PMID: 32347726]
S1	IC₅₀	9.73 nM Compound: Licochalcone A	Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM) Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM)	[PMID: 32347726]
S1-M1-80	IC₅₀	0.31 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	0.41 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	0.61 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	1.03 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	1.53 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	10 μM Compound: Licochalcone A	Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay	[PMID: 32347726]
S1-M1-80	IC₅₀	2.63 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	39.47 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)	[PMID: 32347726]
S1-M1-80	IC₅₀	6.8 μM Compound: Licochalcone A	Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)	[PMID: 32347726]
SiHa	IC₅₀	42.2 μM Compound: 4	Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31539776]
U-87MG ATCC	IC₅₀	> 50 μM Compound: Licochalcone A	Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs	[PMID: 31836442]
WI-38	IC₅₀	90.2 μM Compound: 4	Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay	[PMID: 31539776]

In Vitro

Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

338.40

Formula

C₂₁H₂₂O₄

CAS No.

58749-22-7

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (369.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9551 mL	14.7754 mL	29.5508 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (246 KB) HNMR (270 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. Tang ZH, et al. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016 May 17;6:26241.. . . . [Content Brief]

[2]. Tang ZH, et al. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016 May 17;6:26241.. . . . [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9551 mL	14.7754 mL	29.5508 mL	73.8771 mL
	5 mM	0.5910 mL	2.9551 mL	5.9102 mL	14.7754 mL
	10 mM	0.2955 mL	1.4775 mL	2.9551 mL	7.3877 mL
	15 mM	0.1970 mL	0.9850 mL	1.9701 mL	4.9251 mL
	20 mM	0.1478 mL	0.7388 mL	1.4775 mL	3.6939 mL
	25 mM	0.1182 mL	0.5910 mL	1.1820 mL	2.9551 mL
	30 mM	0.0985 mL	0.4925 mL	0.9850 mL	2.4626 mL
	40 mM	0.0739 mL	0.3694 mL	0.7388 mL	1.8469 mL
	50 mM	0.0591 mL	0.2955 mL	0.5910 mL	1.4775 mL
	60 mM	0.0493 mL	0.2463 mL	0.4925 mL	1.2313 mL
	80 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9235 mL
	100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.7388 mL

Licochalcone A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licochalcone A58749-22-7Licochalcone-AAutophagyInhibitorinhibitorinhibit

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Licochalcone A (Synonyms: Licochalcone-A)

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