2. Metabolic Enzyme/Protease NF-κB
  3. MALT1
  4. MLT-747

MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM.

For research use only. We do not sell to patients.

MLT-747 Chemical Structure

MLT-747 Chemical Structure

CAS No. : 2097853-86-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 300 In-stock
50 mg USD 480 In-stock
100 mg USD 760 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

MLT-747 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1].

IC50 & Target

IC50: 14 nM (MALT1)[1]
In Vitro

MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLT-747 Related Antibodies
Molecular Weight

478.33

Formula

C20H21Cl2N7O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([C@@H](OC)C)N4C(N=C3)=CC(Cl)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0906 mL 10.4530 mL 20.9061 mL
5 mM 0.4181 mL 2.0906 mL 4.1812 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0906 mL 10.4530 mL 20.9061 mL 52.2652 mL
5 mM 0.4181 mL 2.0906 mL 4.1812 mL 10.4530 mL
10 mM 0.2091 mL 1.0453 mL 2.0906 mL 5.2265 mL
15 mM 0.1394 mL 0.6969 mL 1.3937 mL 3.4843 mL
20 mM 0.1045 mL 0.5227 mL 1.0453 mL 2.6133 mL
25 mM 0.0836 mL 0.4181 mL 0.8362 mL 2.0906 mL
30 mM 0.0697 mL 0.3484 mL 0.6969 mL 1.7422 mL
40 mM 0.0523 mL 0.2613 mL 0.5227 mL 1.3066 mL
50 mM 0.0418 mL 0.2091 mL 0.4181 mL 1.0453 mL
60 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8711 mL
80 mM 0.0261 mL 0.1307 mL 0.2613 mL 0.6533 mL
100 mM 0.0209 mL 0.1045 mL 0.2091 mL 0.5227 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MLT-747 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLT-7472097853-86-4MLT747MLT 747MALT1mucosa associated lymphoid tissue lymphoma translocation gene 1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MLT-747
Cat. No.:
HY-124587
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.