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Melinamide  (Synonyms: AC 223; DL-N-(α-Methylbenzyl)linoleamide)

Cat. No.: HY-101722 Purity: 99.94%
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Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

For research use only. We do not sell to patients.

Melinamide Chemical Structure

Melinamide Chemical Structure

CAS No. : 14417-88-0

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Oil
5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 600 In-stock
50 mg USD 850 In-stock
100 mg USD 1150 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Melinamide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

IC50 & Target

IC50: 20.9 μM (cholesterol)[1]
In Vitro

DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Melinamide Related Antibodies
In Vivo

Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

383.61

Formula

C26H41NO
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\CCCCCCCC(NC(C1=CC=CC=C1)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (521.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6068 mL 13.0341 mL 26.0681 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[3]

Rats: 10 diabetic rats are divided into two groups: a cholesterol-fed diabetic group and a melinamide-treated cholesterol-fed diabetic group. Five control rats are injected with citrate buffer only. The rats are fed each diet for 3 weeks after injection. The chol-fed DM group receives a diet (20 g/day) containing 1% cholesterol, 0.5% cholic acid and 5% lard. The melinamide-treated group receives the same diet but supplemented with 0.1% melinamide. Control rats are fed a standard chow (20 g/day). Following a 24-h fast the animals are killed. Blood is collected by aortic puncture and samples of small intestine are retained[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6068 mL 13.0341 mL 26.0681 mL 65.1704 mL
5 mM 0.5214 mL 2.6068 mL 5.2136 mL 13.0341 mL
10 mM 0.2607 mL 1.3034 mL 2.6068 mL 6.5170 mL
15 mM 0.1738 mL 0.8689 mL 1.7379 mL 4.3447 mL
20 mM 0.1303 mL 0.6517 mL 1.3034 mL 3.2585 mL
25 mM 0.1043 mL 0.5214 mL 1.0427 mL 2.6068 mL
30 mM 0.0869 mL 0.4345 mL 0.8689 mL 2.1723 mL
40 mM 0.0652 mL 0.3259 mL 0.6517 mL 1.6293 mL
50 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3034 mL
60 mM 0.0434 mL 0.2172 mL 0.4345 mL 1.0862 mL
80 mM 0.0326 mL 0.1629 mL 0.3259 mL 0.8146 mL
100 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
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Melinamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melinamide14417-88-0AC 223 DL-N-(α-Methylbenzyl)linoleamideAC223AC-223OthersInhibitorinhibitorinhibit

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