Metiamide (Synonyms: SK&F 92058)

Cat. No.: HY-15540 Purity: 98.08%: FAQs
Data Sheet SDS COA Handling Instructions

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Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

For research use only. We do not sell to patients.

Metiamide Chemical Structure

CAS No. : 34839-70-8

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5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

IC₅₀ & Target

Ki: 0.92 uM (H2 receptor)

In Vitro

Metiamide (SK&F 92058) is a competitive with aldehyde substrates and noncompetitive with the Human E3 Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzyme·coenzyme binary complex with K_i values of 0.92 μM glycolaldehyde as the varied substrate^[1]. Data is got as percentage change in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.38

Formula

C₉H₁₆N₄S₂

CAS No.

34839-70-8

Appearance

Solid

Color

White to off-white

SMILES

S=C(NCCSCC1=C(C)N=CN1)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 2.4 mg/mL (9.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.67 mg/mL (6.83 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0920 mL	20.4599 mL	40.9199 mL
5 mM	0.8184 mL	4.0920 mL	8.1840 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.08%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (245 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Alexandra Kikonyogo ,Regina Pietruszko, Cimetidine and Other H2-Receptor Antagonists as Inhibitors of Human E3 Aldehyde Dehydrogenase. Molecular Pharmacology 1997; 52: 2267-271.

[2]. Hendrik Preuss, Prasanta Ghorai1, Anja Kraus, Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors. JPET 2007 vol. 321no. 3 983-995.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.0920 mL	20.4599 mL	40.9199 mL	102.2997 mL
H₂O / DMSO	5 mM	0.8184 mL	4.0920 mL	8.1840 mL	20.4599 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Metiamide Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metiamide34839-70-8SK&F 92058Histamine ReceptorInhibitorinhibitorinhibit

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