2. Immunology/Inflammation Anti-infection
  3. COX Bacterial
  4. Nepafenac

Nepafenac  (Synonyms: AHR 9434; AL 6515)

Cat. No.: HY-17357 Purity: 99.51%
COA Handling Instructions

Molarity Calculator

Nepafenac (AHR 9434; AL 6515; Nevanac) is a COX-2 inhibitor and the original drug of Amfenac.

For research use only. We do not sell to patients.

Nepafenac Chemical Structure

Nepafenac Chemical Structure

CAS No. : 78281-72-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 50 In-stock
Solution
10 mM * 1 mL in DMSO USD 50 In-stock
Solid
25 mg USD 45 In-stock
100 mg USD 120 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Nepafenac:

Nepafenac Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nepafenac (AHR 9434; AL 6515; Nevanac) is a COX-2 inhibitor and the original drug of Amfenac.

IC50 & Target[1][4]

COX-1

64.3 μM (IC50)

COX-2

 

Clinical Trial
Molecular Weight

254.28

Formula

C15H14N2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N)CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (393.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.51%

COA (245 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9327 mL 19.6634 mL 39.3267 mL 98.3168 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL 19.6634 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL 9.8317 mL
15 mM 0.2622 mL 1.3109 mL 2.6218 mL 6.5545 mL
20 mM 0.1966 mL 0.9832 mL 1.9663 mL 4.9158 mL
25 mM 0.1573 mL 0.7865 mL 1.5731 mL 3.9327 mL
30 mM 0.1311 mL 0.6554 mL 1.3109 mL 3.2772 mL
40 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4579 mL
50 mM 0.0787 mL 0.3933 mL 0.7865 mL 1.9663 mL
60 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6386 mL
80 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2290 mL
100 mM 0.0393 mL 0.1966 mL 0.3933 mL 0.9832 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Nepafenac Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nepafenac78281-72-8AHR 9434 AL 6515AHR9434AHR-9434AL6515AL 6515AL-6515COXBacterialCyclooxygenaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nepafenac
Cat. No.:
HY-17357
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.