2. Immunology/Inflammation
  3. COX
  4. Nepafenac-d5

Nepafenac-d5  (Synonyms: AHR-9434-d5; AL-6515-d5)

Cat. No.: HY-17357S Purity: 98.84%
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Nepafenac-d5 is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.

For research use only. We do not sell to patients.

Nepafenac-d<sub>5</sub> Chemical Structure

Nepafenac-d5 Chemical Structure

CAS No. : 1246814-53-8

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5 mg USD 800 In-stock
10 mg USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nepafenac-d5:

Nepafenac-d5 Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

Nepafenac-d5 is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.

Molecular Weight

259.31

Formula

C15H9D5N2O2
CAS No.
Unlabeled CAS

78281-72-8
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=CC=CC(CC(N)=O)=C2N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (385.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8564 mL 19.2819 mL 38.5639 mL
5 mM 0.7713 mL 3.8564 mL 7.7128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8564 mL 19.2819 mL 38.5639 mL 96.4097 mL
5 mM 0.7713 mL 3.8564 mL 7.7128 mL 19.2819 mL
10 mM 0.3856 mL 1.9282 mL 3.8564 mL 9.6410 mL
15 mM 0.2571 mL 1.2855 mL 2.5709 mL 6.4273 mL
20 mM 0.1928 mL 0.9641 mL 1.9282 mL 4.8205 mL
25 mM 0.1543 mL 0.7713 mL 1.5426 mL 3.8564 mL
30 mM 0.1285 mL 0.6427 mL 1.2855 mL 3.2137 mL
40 mM 0.0964 mL 0.4820 mL 0.9641 mL 2.4102 mL
50 mM 0.0771 mL 0.3856 mL 0.7713 mL 1.9282 mL
60 mM 0.0643 mL 0.3214 mL 0.6427 mL 1.6068 mL
80 mM 0.0482 mL 0.2410 mL 0.4820 mL 1.2051 mL
100 mM 0.0386 mL 0.1928 mL 0.3856 mL 0.9641 mL
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Nepafenac-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nepafenac-d51246814-53-8AHR-9434-d5AL-6515-d5COXCyclooxygenaseInhibitorinhibitorinhibit

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