2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Neurokinin A

Neurokinin A  (Synonyms: Substance K; Neurokinin α; Neuromedin L)

Cat. No.: HY-P0197 Purity: 99.68%
COA Handling Instructions

Molarity Calculator

Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neurokinin A Chemical Structure

Neurokinin A Chemical Structure

CAS No. : 86933-74-6

Size Price Stock Quantity
1 mg USD 70 In-stock
5 mg USD 150 In-stock
10 mg USD 260 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Neurokinin A:

Neurokinin A Related Antibodies

Top Publications Citing Use of Products

View All Neurokinin Receptor Isoform Specific Products:

View All Isoforms
NK1 NK2 NK3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

IC50 & Target

NK-2 receptor[1]
In Vitro

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neurokinin A Related Antibodies
Molecular Weight

1133.32

Formula

C50H80N14O14S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

HKTDSFVGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (88.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8824 mL 4.4118 mL 8.8236 mL
5 mM 0.1765 mL 0.8824 mL 1.7647 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8824 mL 4.4118 mL 8.8236 mL 22.0591 mL
5 mM 0.1765 mL 0.8824 mL 1.7647 mL 4.4118 mL
10 mM 0.0882 mL 0.4412 mL 0.8824 mL 2.2059 mL
15 mM 0.0588 mL 0.2941 mL 0.5882 mL 1.4706 mL
20 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1030 mL
25 mM 0.0353 mL 0.1765 mL 0.3529 mL 0.8824 mL
30 mM 0.0294 mL 0.1471 mL 0.2941 mL 0.7353 mL
40 mM 0.0221 mL 0.1103 mL 0.2206 mL 0.5515 mL
50 mM 0.0176 mL 0.0882 mL 0.1765 mL 0.4412 mL
60 mM 0.0147 mL 0.0735 mL 0.1471 mL 0.3677 mL
80 mM 0.0110 mL 0.0551 mL 0.1103 mL 0.2757 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Neurokinin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neurokinin A86933-74-6Substance K Neurokinin α Neuromedin LNeurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Neurokinin A
Cat. No.:
HY-P0197
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.