2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Neurokinin A TFA

Neurokinin A TFA  (Synonyms: Substance K TFA; Neurokinin α TFA; Neuromedin L TFA)

Cat. No.: HY-P0197A Purity: 99.57%
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Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

For research use only. We do not sell to patients.

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Neurokinin A TFA Chemical Structure

Neurokinin A TFA Chemical Structure

CAS No. : 2828433-19-6

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5 mg USD 150 In-stock
10 mg USD 260 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Neurokinin A TFA:

Neurokinin A TFA Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Neurokinin A TFA

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

In Vitro

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neurokinin A TFA Related Antibodies
Molecular Weight

1247.34

Formula

C52H81N14F3O16S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Sequence Shortening

HKTDSFVGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (80.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (40.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8017 mL 4.0085 mL 8.0171 mL
5 mM 0.1603 mL 0.8017 mL 1.6034 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (2.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (20.04 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.8017 mL 4.0085 mL 8.0171 mL 20.0427 mL
5 mM 0.1603 mL 0.8017 mL 1.6034 mL 4.0085 mL
10 mM 0.0802 mL 0.4009 mL 0.8017 mL 2.0043 mL
15 mM 0.0534 mL 0.2672 mL 0.5345 mL 1.3362 mL
20 mM 0.0401 mL 0.2004 mL 0.4009 mL 1.0021 mL
25 mM 0.0321 mL 0.1603 mL 0.3207 mL 0.8017 mL
30 mM 0.0267 mL 0.1336 mL 0.2672 mL 0.6681 mL
40 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5011 mL
DMSO 50 mM 0.0160 mL 0.0802 mL 0.1603 mL 0.4009 mL
60 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3340 mL
80 mM 0.0100 mL 0.0501 mL 0.1002 mL 0.2505 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Neurokinin A TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neurokinin A2828433-19-6Substance KNeurokinin αNeuromedin LNeurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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