Nezukone (Synonyms: C2-deoxyhinokitiol; 4-Isopropyltropone)

Cat. No.: HY-103708 Purity: 98.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.

For research use only. We do not sell to patients.

Nezukone Chemical Structure

CAS No. : 13656-81-0

Size	Price	Stock	Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 308	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 308	In-stock	Estimated Time of Arrival: December 31
Oil
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.

Molecular Weight

148.20

Formula

C₁₀H₁₂O

CAS No.

13656-81-0

Appearance

Oil

Color

Light brown to brown

SMILES

O=C1C=CC=C(C(C)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (674.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (674.76 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7476 mL	33.7382 mL	67.4764 mL
5 mM	1.3495 mL	6.7476 mL	13.4953 mL
10 mM	0.6748 mL	3.3738 mL	6.7476 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.75 mg/mL (25.30 mM); Clear solution

This protocol yields a clear solution of ≥ 3.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.81%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (250 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Grillo AS, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017 May 12;356(6338):608-616. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	6.7476 mL	33.7382 mL	67.4764 mL	168.6910 mL
	5 mM	1.3495 mL	6.7476 mL	13.4953 mL	33.7382 mL
	10 mM	0.6748 mL	3.3738 mL	6.7476 mL	16.8691 mL
	15 mM	0.4498 mL	2.2492 mL	4.4984 mL	11.2461 mL
	20 mM	0.3374 mL	1.6869 mL	3.3738 mL	8.4345 mL
	25 mM	0.2699 mL	1.3495 mL	2.6991 mL	6.7476 mL
	30 mM	0.2249 mL	1.1246 mL	2.2492 mL	5.6230 mL
	40 mM	0.1687 mL	0.8435 mL	1.6869 mL	4.2173 mL
	50 mM	0.1350 mL	0.6748 mL	1.3495 mL	3.3738 mL
	60 mM	0.1125 mL	0.5623 mL	1.1246 mL	2.8115 mL
	80 mM	0.0843 mL	0.4217 mL	0.8435 mL	2.1086 mL
	100 mM	0.0675 mL	0.3374 mL	0.6748 mL	1.6869 mL

Nezukone Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nezukone13656-81-0C2-deoxyhinokitiol 4-IsopropyltroponeOthersInhibitorinhibitorinhibit

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