2. Novaluron

Novaluron is a chemical with insecticide properties, an insect growth regulator, and has adverse effects on mouse sperm.

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Novaluron Chemical Structure

Novaluron Chemical Structure

CAS No. : 116714-46-6

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Novaluron:

Novaluron Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Novaluron is a chemical with insecticide properties, an insect growth regulator, and has adverse effects on mouse sperm[1][2].

In Vitro

Novaluron (0-100 μM, 90 min) inhibits the viability of mouse spermatocytes[1].
Novaluron (10-100 µM, 90 min) significantly reduces the number of acrosome-reactive sperm, significantly reduces sperm motility, and changes PKA activity and tyrosine phosphorylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Novaluron Related Antibodies

Cell Viability Assay[1]

Cell Line: Sperm cells
Concentration: 0, 0.1, 1, 10, 100 μM
Incubation Time: 90 min
Result: Inhibited cell viability.

Western Blot Analysis[1]

Cell Line: Sperm cells
Concentration: 0, 0.1, 1, 10, 100 μM
Incubation Time: 90 min
Result: Altered in PKA activity and tyrosine phosphorylation.
Molecular Weight

492.70

Formula

C17H9ClF8N2O4
CAS No.
Appearance

Solid

Color

White to gray

SMILES

O=C(NC(NC1=CC=C(OC(F)(F)C(F)OC(F)(F)F)C(Cl)=C1)=O)C2=C(F)C=CC=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (243.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0296 mL 10.1482 mL 20.2963 mL
5 mM 0.4059 mL 2.0296 mL 4.0593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 3 mg/mL (6.09 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3 mg/mL (6.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0296 mL 10.1482 mL 20.2963 mL 50.7408 mL
5 mM 0.4059 mL 2.0296 mL 4.0593 mL 10.1482 mL
10 mM 0.2030 mL 1.0148 mL 2.0296 mL 5.0741 mL
15 mM 0.1353 mL 0.6765 mL 1.3531 mL 3.3827 mL
20 mM 0.1015 mL 0.5074 mL 1.0148 mL 2.5370 mL
25 mM 0.0812 mL 0.4059 mL 0.8119 mL 2.0296 mL
30 mM 0.0677 mL 0.3383 mL 0.6765 mL 1.6914 mL
40 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL
50 mM 0.0406 mL 0.2030 mL 0.4059 mL 1.0148 mL
60 mM 0.0338 mL 0.1691 mL 0.3383 mL 0.8457 mL
80 mM 0.0254 mL 0.1269 mL 0.2537 mL 0.6343 mL
100 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5074 mL
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Novaluron Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Novaluron116714-46-6Pesticidesinhibit sperm motilityInhibitorinhibitorinhibit

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