2. GPCR/G Protein
  3. TSH Receptor
  4. Org41841

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

For research use only. We do not sell to patients.

Org41841 Chemical Structure

Org41841 Chemical Structure

CAS No. : 301847-37-0

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 210 In-stock
10 mg USD 360 In-stock
25 mg USD 790 In-stock
50 mg USD 1280 In-stock
100 mg USD 2050 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Org41841 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

IC50 & Target

EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.3 μM
Compound: 3,Org 41841
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
[PMID: 16789744]
HEK293 EC50
6.5 μM
Compound: 3,Org 41841
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
[PMID: 16789744]
In Vitro

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Org41841 Related Antibodies
Molecular Weight

402.53

Formula

C19H22N4O2S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(N)C2=C(C3=CC=CC(OC)=C3)N=C(SC)N=C2S1)NC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4843 mL 12.4214 mL 24.8429 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Kinase Assay
[1]

Transfected cells are cultured for 48 h before incubation for 1 h in serum-free Dulbecco's modified Eagle's medium containing 1 mM 3-isobutyl-1-methylxanthine and bovine thyroid-stimulating hormone (TSH) (0 to 1.8 μM) or human LH (0.1 to 1000 ng) or Org41841 (0 to100 μM) in a humidified 5% CO2 incubator. Following aspiration of the medium, cells are lysed using lysis buffer 1 of the cAMP Biotrak Enzymeimmunoassay System. The cAMP content of the cell lysate is determined and data are analyzed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4843 mL 12.4214 mL 24.8429 mL 62.1072 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL 12.4214 mL
10 mM 0.2484 mL 1.2421 mL 2.4843 mL 6.2107 mL
15 mM 0.1656 mL 0.8281 mL 1.6562 mL 4.1405 mL
20 mM 0.1242 mL 0.6211 mL 1.2421 mL 3.1054 mL
25 mM 0.0994 mL 0.4969 mL 0.9937 mL 2.4843 mL
30 mM 0.0828 mL 0.4140 mL 0.8281 mL 2.0702 mL
40 mM 0.0621 mL 0.3105 mL 0.6211 mL 1.5527 mL
50 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2421 mL
60 mM 0.0414 mL 0.2070 mL 0.4140 mL 1.0351 mL
80 mM 0.0311 mL 0.1553 mL 0.3105 mL 0.7763 mL
100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.6211 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Org41841 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org41841301847-37-0Org 41841Org-41841TSH ReceptorThyrotropin receptorThyroid-stimulating hormone ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Org41841
Cat. No.:
HY-100271
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.