2. Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel
  3. Apoptosis Caspase iGluR
  4. PEAQX tetrasodium hydrate

PEAQX tetrasodium hydrate  (Synonyms: NVP-AAM077 tetrasodium hydrate)

Cat. No.: HY-12294A Purity: ≥98.0%
SDS COA Handling Instructions

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PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.

For research use only. We do not sell to patients.

PEAQX tetrasodium hydrate Chemical Structure

PEAQX tetrasodium hydrate Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of PEAQX tetrasodium hydrate:

PEAQX tetrasodium hydrate Related Antibodies

Top Publications Citing Use of Products

    PEAQX tetrasodium hydrate purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.

    View All Caspase Isoform Specific Products:

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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    AMPA Receptor NMDA Receptor Kainate Receptor

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
    IC50 & Target

    NMDA Receptor

     

    In Vitro

    PEAQX tetrasodium hydrate (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PEAQX tetrasodium hydrate Related Antibodies
    In Vivo

    PEAQX tetrasodium hydrate (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner[2].
    PEAQX tetrasodium hydrate (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Pups obtained from deliveries of pregnant female Sprague-Dawley rats[2].
    Dosage: 10, 20, 40 mg/kg
    Administration: Subcutaneous injection (s.c.)
    Result: Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.
    Animal Model: 11-week old C57BL/6 mice with cerebral ischemia[3].
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection (i.p.); once daily; 4 days
    Result: Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.
    Molecular Weight

    560.15

    Formula

    C17H15BrN3Na4O6P
    Appearance

    Solid

    Color

    Light yellow to khaki

    SMILES

    BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7852 mL 8.9262 mL 17.8524 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (178.52 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥98.0%

    SDS (252 KB)

    COA (255 KB) HNMR (297 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.7852 mL 8.9262 mL 17.8524 mL 44.6309 mL
    5 mM 0.3570 mL 1.7852 mL 3.5705 mL 8.9262 mL
    10 mM 0.1785 mL 0.8926 mL 1.7852 mL 4.4631 mL
    15 mM 0.1190 mL 0.5951 mL 1.1902 mL 2.9754 mL
    20 mM 0.0893 mL 0.4463 mL 0.8926 mL 2.2315 mL
    25 mM 0.0714 mL 0.3570 mL 0.7141 mL 1.7852 mL
    30 mM 0.0595 mL 0.2975 mL 0.5951 mL 1.4877 mL
    40 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1158 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    PEAQX tetrasodium hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PEAQX tetrasodiumNVP-AAM077 tetrasodiumApoptosisCaspaseiGluRIonotropic glutamate receptorsorally activeNMDAcaspase-3cerebral ischemialearning disorderInhibitorinhibitorinhibit

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