PEAQX (Synonyms: NVP-AAM077)

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PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC₅₀ values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.

For research use only. We do not sell to patients.

PEAQX Chemical Structure

CAS No. : 459836-30-7

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Other In-stock Forms of PEAQX:

PEAQX tetrasodium hydrate

Other Forms of PEAQX:

PEAQX tetrasodium hydrate In-stock
(Rac)-PEAQX Get quote

5 Publications Citing Use of MCE PEAQX

: PEAQX purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12. [Abstract]; PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

In Vitro

PEAQX (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PEAQX (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner^[2].
PEAQX (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pups obtained from deliveries of pregnant female Sprague-Dawley rats^[2].
Dosage:	10, 20, 40 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.

Animal Model:	11-week old C57BL/6 mice with cerebral ischemia^[3].
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); once daily; 4 days
Result:	Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.

Molecular Weight

454.21

Formula

C₁₇H₁₇BrN₃O₅P

CAS No.

459836-30-7

SMILES

O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

PEAQX is dissolved in DMSO and diluted with sterile saline^[3].

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102. [Content Brief]

[2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91. [Content Brief]

[3]. Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175. [Content Brief]

PEAQX Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEAQX459836-30-7NVP-AAM077CaspaseApoptosisiGluRIonotropic glutamate receptorsorally activeNMDAcaspase-3cerebral ischemialearning disorderInhibitorinhibitorinhibit

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