PH-064 (Synonyms: BIM-46187)

Name: PH-064
Brand: MedChemExpress
SKU: HY-10499
Rating: 4.5 (1 reviews)

Cat. No.: HY-10499 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

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PH-064 (BIM-46187) is an inhibitor of heterotrimeric G-protein complex.

For research use only. We do not sell to patients.

PH-064 Chemical Structure

CAS No. : 892546-37-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 380	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 380	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 435	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 870	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1395	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2230	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PH-064:

PH-064 (tetra(hydrochloride)) Get quote

1 Publications Citing Use of MCE PH-064

•Phytomedicine. 2023 Nov 15, 155200.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PH-064 (BIM-46187) is an inhibitor of heterotrimeric G-protein complex.

Molecular Weight

795.11

Formula

C₄₄H₅₈N₈O₂S₂

CAS No.

892546-37-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@H](CSSC[C@@H](C(N1CCN2C([C@@H]1CC3CCCCC3)=NC(C4=CC=CC=C4)=C2)=O)N)N)N([C@H]5CC6CCCCC6)CCN(C5=N7)C=C7C8=CC=CC=C8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (125.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2577 mL	6.2884 mL	12.5769 mL
5 mM	0.2515 mL	1.2577 mL	2.5154 mL
10 mM	0.1258 mL	0.6288 mL	1.2577 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) HNMR (327 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Favre-Guilmard C, et al. The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine. Eur J Pharmacol. 2008 Oct 10;594(1-3):70-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2577 mL	6.2884 mL	12.5769 mL	31.4422 mL
	5 mM	0.2515 mL	1.2577 mL	2.5154 mL	6.2884 mL
	10 mM	0.1258 mL	0.6288 mL	1.2577 mL	3.1442 mL
	15 mM	0.0838 mL	0.4192 mL	0.8385 mL	2.0961 mL
	20 mM	0.0629 mL	0.3144 mL	0.6288 mL	1.5721 mL
	25 mM	0.0503 mL	0.2515 mL	0.5031 mL	1.2577 mL
	30 mM	0.0419 mL	0.2096 mL	0.4192 mL	1.0481 mL
	40 mM	0.0314 mL	0.1572 mL	0.3144 mL	0.7861 mL
	50 mM	0.0252 mL	0.1258 mL	0.2515 mL	0.6288 mL
	60 mM	0.0210 mL	0.1048 mL	0.2096 mL	0.5240 mL
	80 mM	0.0157 mL	0.0786 mL	0.1572 mL	0.3930 mL
	100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.3144 mL

PH-064 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PH-064892546-37-1BIM-46187PH064PH 064BIM46187BIM 46187OthersInhibitorinhibitorinhibit

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PH-064 (Synonyms: BIM-46187)

Customer Review

Other Forms of PH-064:

PH-064 Related Antibodies

1 Publications Citing Use of MCE PH-064

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

PH-064 Related Classifications

Keywords:

Your Recently Viewed Products:

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