2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. AMPK PPAR Glucokinase
  4. Palmitelaidic Acid

Palmitelaidic Acid  (Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid)

Cat. No.: HY-N2341 Purity: ≥99.0%
COA Handling Instructions

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Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

For research use only. We do not sell to patients.

Palmitelaidic Acid Chemical Structure

Palmitelaidic Acid Chemical Structure

CAS No. : 10030-73-6

Size Price Stock Quantity
Solvent
10 mg (393 mM * 100 μL in Ethanol) USD 50 In-stock
Solvent
25 mg (393 mM * 250 μL in Ethanol) USD 100 In-stock
Solvent
50 mg (393 mM * 500 μL in Ethanol) USD 160 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Palmitelaidic Acid:

Palmitelaidic Acid Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

IC50 & Target[2]

AMPK

 

PPARα

 

Glucokinase

 

In Vitro

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palmitelaidic Acid Related Antibodies
In Vivo

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα[2]. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

254.41

Formula

C16H30O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source

 beef samples
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (393.07 mM; Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (238 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[2]

Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h, injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.9307 mL 19.6533 mL 39.3066 mL 98.2666 mL
5 mM 0.7861 mL 3.9307 mL 7.8613 mL 19.6533 mL
10 mM 0.3931 mL 1.9653 mL 3.9307 mL 9.8267 mL
15 mM 0.2620 mL 1.3102 mL 2.6204 mL 6.5511 mL
20 mM 0.1965 mL 0.9827 mL 1.9653 mL 4.9133 mL
25 mM 0.1572 mL 0.7861 mL 1.5723 mL 3.9307 mL
30 mM 0.1310 mL 0.6551 mL 1.3102 mL 3.2756 mL
40 mM 0.0983 mL 0.4913 mL 0.9827 mL 2.4567 mL
50 mM 0.0786 mL 0.3931 mL 0.7861 mL 1.9653 mL
60 mM 0.0655 mL 0.3276 mL 0.6551 mL 1.6378 mL
80 mM 0.0491 mL 0.2457 mL 0.4913 mL 1.2283 mL
100 mM 0.0393 mL 0.1965 mL 0.3931 mL 0.9827 mL
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Palmitelaidic Acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitelaidic Acid10030-73-69-trans-Hexadecenoic acid trans-Palmitoleic acidAMPKPPARGlucokinaseAMP-activated protein kinasePeroxisome proliferator-activated receptorsHexokinase IVHexokinase DInhibitorinhibitorinhibit

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