Phosphorylethanolamine (Synonyms: Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine)

Name: Phosphorylethanolamine
Brand: MedChemExpress
SKU: HY-N5034
Rating: 5.0 (2 reviews)

Cat. No.: HY-N5034 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases.

For research use only. We do not sell to patients.

Phosphorylethanolamine Chemical Structure

CAS No. : 1071-23-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	USD 30	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Phosphorylethanolamine:

Phosphorylethanolamine-d₄ Get quote
Phosphorylethanolamine (Standard) Get quote

2 Publications Citing Use of MCE Phosphorylethanolamine

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

Phosphorylethanolamine (Monoaminoethyl phosphate) arrests A2058 cells at the G2/M phase of the cell cycle and inhibits their proliferation, migration, and adhesion capabilities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	A2058 cells, B16F10 cells
Concentration:	4.69-300 mM
Incubation Time:	24 h
Result:	Not only reduced viability but also blocked the capacity of A2058 cells of forming new clones.

Molecular Weight

141.06

Formula

C₂H₈NO₄P

CAS No.

1071-23-4

Appearance

Solid

Color

White to off-white

SMILES

NCCOP(O)(O)=O

Structure Classification

Others

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (886.15 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0892 mL	35.4459 mL	70.8918 mL
5 mM	1.4178 mL	7.0892 mL	14.1784 mL
10 mM	0.7089 mL	3.5446 mL	7.0892 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (708.92 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (476 KB)

COA (244 KB) HNMR (271 KB)

Handling Instructions (2659 KB)

References

[1]. Kinoshita Y, et al. Phosphorylethanolamine content of human brain tumors. Neurol Med Chir (Tokyo). 1994 Dec;34(12):803-6. [Content Brief]

[2]. Hui SCN, et al. In vivo spectral editing of phosphorylethanolamine. Magn Reson Med. 2022 Jan;87(1):50-56. [Content Brief]

[3]. Calzada E,et al. Phosphatidylethanolamine Metabolism in Health and Disease. Int Rev Cell Mol Biol. 2016;321:29-88. doi: 10.1016/bs.ircmb.2015.10.001. [Content Brief]

[4]. van der Veen JN, et al. A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. FASEB J. 2019 Apr;33(4):5045-5057. [Content Brief]

[5]. Nesic I, et al. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 2012 Feb;11(1):63-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.0892 mL	35.4459 mL	70.8918 mL	177.2296 mL
	5 mM	1.4178 mL	7.0892 mL	14.1784 mL	35.4459 mL
	10 mM	0.7089 mL	3.5446 mL	7.0892 mL	17.7230 mL
	15 mM	0.4726 mL	2.3631 mL	4.7261 mL	11.8153 mL
	20 mM	0.3545 mL	1.7723 mL	3.5446 mL	8.8615 mL
	25 mM	0.2836 mL	1.4178 mL	2.8357 mL	7.0892 mL
	30 mM	0.2363 mL	1.1815 mL	2.3631 mL	5.9077 mL
	40 mM	0.1772 mL	0.8861 mL	1.7723 mL	4.4307 mL
	50 mM	0.1418 mL	0.7089 mL	1.4178 mL	3.5446 mL
	60 mM	0.1182 mL	0.5908 mL	1.1815 mL	2.9538 mL
	80 mM	0.0886 mL	0.4431 mL	0.8861 mL	2.2154 mL
	100 mM	0.0709 mL	0.3545 mL	0.7089 mL	1.7723 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Phosphorylethanolamine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphorylethanolamine1071-23-4Monoaminoethyl NSC 254167 O-PhosphoethanolamineNSC254167NSC 254167NSC-254167Endogenous MetabolitePEExtracranial tumorsMetabolismInhibitorinhibitorinhibit

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Phosphorylethanolamine (Synonyms: Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine)

Customer Review

Other Forms of Phosphorylethanolamine:

Phosphorylethanolamine Related Antibodies

2 Publications Citing Use of MCE Phosphorylethanolamine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Phosphorylethanolamine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Phosphorylethanolamine Related Classifications

Keywords:

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