2. Anti-infection
  3. Bacterial
  4. Pymetrozine

Pymetrozine  (Synonyms: CGA 215944)

Cat. No.: HY-B0821 Purity: 99.78%
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Pymetrozine is a feeding inhibitor of Homoptera, in preventing transmission of cauliflower mosaic caulimovirus by the aphid species Myzus persicae (Sulzer).

For research use only. We do not sell to patients.

Pymetrozine Chemical Structure

Pymetrozine Chemical Structure

CAS No. : 123312-89-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pymetrozine:

Pymetrozine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pymetrozine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pymetrozine is a feeding inhibitor of Homoptera, in preventing transmission of cauliflower mosaic caulimovirus by the aphid species Myzus persicae (Sulzer).

IC50 & Target

Homoptera[1]
In Vivo

Pymetrozine, a fast-acting and selective inhibitor of aphid feeding. In-situ studies with electronic monitoring of feeding behaviour. Pymetrozine, a pyridine azomethine compound, represents a novel insecticide with a selective activity against homopteran insects. It acts in a unique way: aphids are not knocked down on contact but seem to die of starvation. This implies an effect of Pymetrozine on feeding behaviour. The aim of the present work is to elucidate how and at which step Pymetrozine interferes with the complex mechanisms underlying phloem feeding. The effect of Pymetrozine, applied in various ways, on different phases of stylet penetration and feeding activity of individual aphids is studied using the Electrical Penetration Graph technique (EPG). Initial choice experiments indicated that Pymetrozine does not have a deterrent or antifeedant action. Topical application (150 ng/mg fresh weight) inhibits stylet insertion into the plant. When injected, less than 30 ng/mg is sufficient to produce the same effect. When Pymetrozine is systemically applied via plant spraying or root uptake, aphids started feeding normally. After some time, however, they withdrew their stylets from the phloem and walked around with unaffected locomotion. At low doses aphids eventually recovered and resumed feeding. High doses, however, irreversibly disrupted feeding and prevented stylet reinsertion. Aphid motility is not affected up to an estimated haemolymph concentration of 1 mM Pymetrozine. Aphids which eventually stopped feeding on Pymetrozine-treated plants showed EPGs with distorted salivation/ingestion patterns[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

217.23

Formula

C10H11N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NN=C(C)CN1/N=C/C2=CC=CN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (153.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6034 mL 23.0171 mL 46.0342 mL
5 mM 0.9207 mL 4.6034 mL 9.2068 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.78%

COA (248 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6034 mL 23.0171 mL 46.0342 mL 115.0854 mL
5 mM 0.9207 mL 4.6034 mL 9.2068 mL 23.0171 mL
10 mM 0.4603 mL 2.3017 mL 4.6034 mL 11.5085 mL
15 mM 0.3069 mL 1.5345 mL 3.0689 mL 7.6724 mL
20 mM 0.2302 mL 1.1509 mL 2.3017 mL 5.7543 mL
25 mM 0.1841 mL 0.9207 mL 1.8414 mL 4.6034 mL
30 mM 0.1534 mL 0.7672 mL 1.5345 mL 3.8362 mL
40 mM 0.1151 mL 0.5754 mL 1.1509 mL 2.8771 mL
50 mM 0.0921 mL 0.4603 mL 0.9207 mL 2.3017 mL
60 mM 0.0767 mL 0.3836 mL 0.7672 mL 1.9181 mL
80 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4386 mL
100 mM 0.0460 mL 0.2302 mL 0.4603 mL 1.1509 mL
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Pymetrozine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pymetrozine123312-89-0CGA 215944CGA215944CGA-215944BacterialInhibitorinhibitorinhibit

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