2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13988
    AT-56 162640-98-4 ≥98.0%
    AT-56 is a potent, selective and orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS), with an IC50 of 95 μM and Ki of 75 μM. AT-56 could selectively suppress the drowsiness or pain reaction mediated by L-PGDS-catalyzed PGD2.
    AT-56
  • HY-N0220
    Dauricine 524-17-4 99.91%
    Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.
    Dauricine
  • HY-N0494
    Gentiopicroside 20831-76-9 99.83%
    Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.
    Gentiopicroside
  • HY-N0669
    Stevioside 57817-89-7
    Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities.
    Stevioside
  • HY-N0928
    Mimosine 500-44-7 99.92%
    Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.
    Mimosine
  • HY-N7264
    7α-Hydroxycholesterol 566-26-7 ≥98.0%
    7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.
    7α-Hydroxycholesterol
  • HY-117235
    Diallyl Trisulfide 2050-87-5
    Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer.
    Diallyl Trisulfide
  • HY-136179
    ZAP-180013 873080-25-2 ≥98.0%
    ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).
    ZAP-180013
  • HY-155864
    AJ2-30 2700322-79-6 99.92%
    AJ2-30 is a SLCl5A4 inhibitor. AJ2-30 inhibits TLR9-mediated B cell activation. AJ2-30 block endogenous NOD signaling in human and mouse macrophages. AJ2-30 can be used for research of inflammation.
    AJ2-30
  • HY-B0167A
    Sodium Salicylate 54-21-7 ≥98.0%
    Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.
    Sodium Salicylate
  • HY-B0801A
    Fexofenadine hydrochloride 153439-40-8 99.86%
    Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research.
    Fexofenadine hydrochloride
  • HY-P10136
    IA9 98.36%
    IA9 (human TREM-2 182-190) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model.
    IA9
  • HY-15985
    CTX-0294885 1439934-41-4 99.43%
    CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer.
    CTX-0294885
  • HY-B2123
    Lactose 63-42-3 ≥98.0%
    Lactose is a β-galactoside consisting of galactose and glucose residues，the main carbohydrate in mammalian breast milk. Lactose，a macronutrient and an inducer of host innate immune responses，possesses immune modulatory functions.
    Lactose
  • HY-D0875
    PIPES 5625-37-6 ≥99.0%
    PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry.
    PIPES
  • HY-109053
    Delgocitinib 1263774-59-9 99.87%
    Delgocitinib (JTE-052) is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
    Delgocitinib
  • HY-160412
    Balinatunfib 2248726-53-4 98.40%
    Balinatunfib (SAR-441566) is an orally active TNFR1 signaling inhibitor. Balinatunfib changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its heterotrimerization with TNFR1 but not TNFR2, thereby blocking TNFR1 signaling. Balinatunfib can be used for the study of autoimmune diseases.
    Balinatunfib
  • HY-P99020
    Fresolimumab 948564-73-6 99.51%
    Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease.
    Fresolimumab
  • HY-112125A
    KRN2 bromide 1390654-28-0 ≥98.0%
    KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM.
    KRN2 bromide
  • HY-B0154
    Fluticasone (propionate) 80474-14-2 99.82%
    Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
    Fluticasone (propionate)
Cat. No. Product Name / Synonyms Application Reactivity