S-Allyl-L-cysteine

Name: S-Allyl-L-cysteine
Brand: MedChemExpress
SKU: HY-W013573
Rating: 4.5 (1 reviews)

Cat. No.: HY-W013573 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

For research use only. We do not sell to patients.

S-Allyl-L-cysteine Chemical Structure

CAS No. : 21593-77-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 28	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of S-Allyl-L-cysteine:

S-Allyl-L-cysteine (Standard) Get quote

1 Publications Citing Use of MCE S-Allyl-L-cysteine

•Biochem Biophys Res Commun. 2024 Jul 2:730:150341. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

In Vitro

It is found that S-Allyl-L-cysteine could protect against amyloid-protein (A)-and tunicamycin-induced cell death in differentiated PC12 cells. Simultaneously applied S-Allyl-L-cysteine (1 μM) suppresses the cell death induced by Aβ_25-35 and Aβ_1-40 in a concentration-dependent manner, and neuronal integrity is almost completely retained. Simultaneously applied S-Allyl-L-cysteine significantly decreases the Aβ-induced level of ROS. The TEAC value of S-Allyl-L-cysteine is lower than that of oxidized GSH, and no antioxidant activity is observed. Intracellular GSH levels remains unaffected by treatment of neurons with S-Allyl-L-cysteine for 24 h. Furthermore, the increase in caspase-12 protein expression is suppressed by simultaneously adding 1 μM S-Allyl-L-cysteine ^[1]. S-Allyl-L-cysteine up to a concentration 1.0 mM does not exhibit any cytotoxic impact on morphology of myoblast and myotubes in culture observed under bright field microscope. TNF treatment leads to a significant decrease in the intracellular CK activity while S-Allyl-L-cysteine pre-treatment to TNF treated myotubes decreases the release of CK in media. S-Allyl-L-cysteine pre-treatment decreases the level of active form of this enzyme in S-Allyl-L-cysteine+TNF group. Similar observations are recorded at mRNA level for caspase-3. These results illustrate that S-Allyl-L-cysteine regulates apoptotic signals via suppressing the transcription and thus protein expression of caspase-3^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

161.22

Formula

C₆H₁₁NO₂S

CAS No.

21593-77-1

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CSCC=C)C(O)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 16.67 mg/mL (103.40 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2027 mL	31.0135 mL	62.0270 mL
5 mM	1.2405 mL	6.2027 mL	12.4054 mL
10 mM	0.6203 mL	3.1014 mL	6.2027 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (310.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.64%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (244 KB) HNMR (191 KB) LCMS (336 KB)

Handling Instructions (2659 KB)

References

[1]. Kosuge Y, et al. S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death. Neuroscience. 2003;122(4):885-95. [Content Brief]

[2]. Dutt V, et al. S-allyl cysteine inhibits TNFα-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. 2018 Apr;1862(4):895-906. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2027 mL	31.0135 mL	62.0270 mL	155.0676 mL
	5 mM	1.2405 mL	6.2027 mL	12.4054 mL	31.0135 mL
	10 mM	0.6203 mL	3.1014 mL	6.2027 mL	15.5068 mL
	15 mM	0.4135 mL	2.0676 mL	4.1351 mL	10.3378 mL
	20 mM	0.3101 mL	1.5507 mL	3.1014 mL	7.7534 mL
	25 mM	0.2481 mL	1.2405 mL	2.4811 mL	6.2027 mL
	30 mM	0.2068 mL	1.0338 mL	2.0676 mL	5.1689 mL
	40 mM	0.1551 mL	0.7753 mL	1.5507 mL	3.8767 mL
	50 mM	0.1241 mL	0.6203 mL	1.2405 mL	3.1014 mL
	60 mM	0.1034 mL	0.5169 mL	1.0338 mL	2.5845 mL
	80 mM	0.0775 mL	0.3877 mL	0.7753 mL	1.9383 mL
	100 mM	0.0620 mL	0.3101 mL	0.6203 mL	1.5507 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.