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Sodium Picosulfate  (Synonyms: Sodium Picosulphate)

Cat. No.: HY-B0544 Purity: ≥98.0%
COA Handling Instructions

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Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications.

For research use only. We do not sell to patients.

Sodium Picosulfate Chemical Structure

Sodium Picosulfate Chemical Structure

CAS No. : 10040-45-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium Picosulfate:

Sodium Picosulfate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications[1][2][3][4].

In Vitro

Sodium Picosulfate (400, 800, 1600 μg/mL) has different toxicity to rabbit, rat and human hepatocytes, and rat hepatocytes are the best tolerated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium Picosulfate Related Antibodies
In Vivo

Sodium Picosulfate (10 mg/kg, dissolved in 0.3% tragacanth in water, intragastric administration) has no significant effect on the proliferation of epithelial cells in the ileum and colon of rats[2].
Sodium Picosulfate (2.5, 10 mg/kg/day, dissolved in 0.5% tragacanth gum, intragastric administration) does not cause chronic changes in colon movement in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

481.41

Formula

C18H13NNa2O8S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(OC1=CC=C(C=C1)C(C2=CC=CC=N2)C3=CC=C(OS(=O)(O[Na])=O)C=C3)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (207.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0772 mL 10.3862 mL 20.7723 mL
5 mM 0.4154 mL 2.0772 mL 4.1545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (207.72 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (268 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.0772 mL 10.3862 mL 20.7723 mL 51.9308 mL
5 mM 0.4154 mL 2.0772 mL 4.1545 mL 10.3862 mL
10 mM 0.2077 mL 1.0386 mL 2.0772 mL 5.1931 mL
15 mM 0.1385 mL 0.6924 mL 1.3848 mL 3.4621 mL
20 mM 0.1039 mL 0.5193 mL 1.0386 mL 2.5965 mL
25 mM 0.0831 mL 0.4154 mL 0.8309 mL 2.0772 mL
30 mM 0.0692 mL 0.3462 mL 0.6924 mL 1.7310 mL
40 mM 0.0519 mL 0.2597 mL 0.5193 mL 1.2983 mL
50 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0386 mL
60 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8655 mL
80 mM 0.0260 mL 0.1298 mL 0.2597 mL 0.6491 mL
100 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5193 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium Picosulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium Picosulfate10040-45-6Sodium PicosulphateOthersColon motilityHepatocytesElectromyographyColonoscopyInhibitorinhibitorinhibit

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