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TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.

For research use only. We do not sell to patients.

TY-51469 Chemical Structure

TY-51469 Chemical Structure

CAS No. : 603987-59-3

Size Price Stock Quantity
1 mg USD 230 In-stock
5 mg USD 580 In-stock
10 mg USD 870 In-stock
25 mg USD 1480 In-stock
50 mg USD 1990 In-stock
100 mg USD 2650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.

IC50 & Target

IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]
In Vivo

TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

526.60

Formula

C20H15FN2O6S4
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(C1=CSC(C2=CC=C(NS(=O)(C3=C(C)C4=CC(F)=CC=C4S3)=O)C(S(=O)(C)=O)=C2)=N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (63.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8990 mL 9.4949 mL 18.9897 mL
5 mM 0.3798 mL 1.8990 mL 3.7979 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Rats[1]

The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1].

Mice[1]

the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8990 mL 9.4949 mL 18.9897 mL 47.4744 mL
5 mM 0.3798 mL 1.8990 mL 3.7979 mL 9.4949 mL
10 mM 0.1899 mL 0.9495 mL 1.8990 mL 4.7474 mL
15 mM 0.1266 mL 0.6330 mL 1.2660 mL 3.1650 mL
20 mM 0.0949 mL 0.4747 mL 0.9495 mL 2.3737 mL
25 mM 0.0760 mL 0.3798 mL 0.7596 mL 1.8990 mL
30 mM 0.0633 mL 0.3165 mL 0.6330 mL 1.5825 mL
40 mM 0.0475 mL 0.2374 mL 0.4747 mL 1.1869 mL
50 mM 0.0380 mL 0.1899 mL 0.3798 mL 0.9495 mL
60 mM 0.0316 mL 0.1582 mL 0.3165 mL 0.7912 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TY-51469603987-59-3TY51469TY 51469OthersInhibitorinhibitorinhibit

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