2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor

5-HT Receptor

Receptor

Serotonin Receptor; 5-hydroxytryptamine Receptor

5-HT Receptor

Related Products

PDF 7.25 MB

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1115S1
    Buspirone-d8 dihydrochloride
    		Agonist
    Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.
    Buspirone-d<sub>8</sub> dihydrochloride
  • HY-B2089R
    Cinitapride (Standard)
    		Modulator
    Cinitapride (Standard) is the analytical standard of Cinitapride. This product is intended for research and analytical applications. Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research.
    Cinitapride (Standard)
  • HY-145531
    Mirtazapine N-oxide
    		Control
    Mirtazapine N-oxide is a metabolite of Mirtazapine (HY-B0352).
    Mirtazapine N-oxide
  • HY-101377B
    S(-)-8-OH-DPAT hydrobromide
    		Agonist
    S(-)-8-OH-DPAT (S(-)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is an enantiomer of 8-OH-DPAT hydrobromide. 8-OH-DPAT hydrobromide is a potent, selective 5-HT1A agonist with a pIC50 of 8.19.
    S(-)-8-OH-DPAT hydrobromide
  • HY-W700240
    Triazolomethylindole-3-acetic acid
    		Control
    Triazolomethylindole-3-acetic acid is a metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Rizatriptan HY-B0206).
    Triazolomethylindole-3-acetic acid
  • HY-123205R
    Oxatomide (Standard)
    		Inhibitor
    Oxatomide (Standard) is the analytical standard of Oxatomide. This product is intended for research and analytical applications. Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.
    Oxatomide (Standard)
  • HY-109036
    Landipirdine
    		Antagonist 99.80%
    Landipirdine is a selective antagonist of 5-HT6R. Landipirdine has great effect on the hERG pharmacophore.
    Landipirdine
  • HY-70050CS
    Alosetron-d3 hydrochloride
    		Antagonist ≥99.0%
    Alosetron-d3 (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.
    Alosetron-d<sub>3</sub> hydrochloride
  • HY-124367
    25B-NBF hydrochloride
    		Agonist
    25B-NBF hydrochloride is a highly potent agonist for the 5-HT2C receptor binds human 5-HT2A receptors and rat 5-HT2C receptors with pKi values of 8.57 and 7.73, respectively.
    25B-NBF hydrochloride
  • HY-14940S
    Volinanserin-d4 hydrochloride
    		Antagonist
    Volinanserin-d4 (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].
    Volinanserin-d<sub>4</sub> hydrochloride
  • HY-14539A
    Clozapine hydrochloride
    		Modulator
    Clozapine hydrochloride (HF 1854 hydrochloride) is an antipsychotic used for the research of schizophrenia. Clozapine hydrochloride has high affinity for a number of neuroreceptors. Clozapine hydrochloride is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine hydrochloride inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine hydrochloride is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
    Clozapine hydrochloride
  • HY-15543
    CP-809101
    		Agonist
    CP-809101 is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.
    CP-809101
  • HY-19682
    Enciprazine
    		Agonist
    Enciprazine is a potent agonist 5-HT1A receptor. Enciprazine shows anxiolytic activity, and can be used in the research of anxiety disorders, and depression.
    Enciprazine
  • HY-101365AR
    RS-102221 hydrochloride (Standard)
    		Antagonist
    RS-102221 (hydrochloride) (Standard) is the analytical standard of RS-102221 (hydrochloride). This product is intended for research and analytical applications. RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.
    RS-102221 hydrochloride (Standard)
  • HY-108256S
    Melitracen-d6 hydrochloride
    		Inhibitor
    Melitracen-d6 (hydrochloride) is the deuterium labeled Melitracen hydrochloride. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space[1][2].
    Melitracen-d<sub>6</sub> hydrochloride
  • HY-W181626A
    Tiprenolol hydrochloride
    		Inhibitor
    Tiprenolol hydrochloride is a β-adrenoceptor blocker. Tiprenolol hydrochloride abolished ventricular arrhythmias induced by intravenous epinephrine in dogs receiving halothane inhalation.
    Tiprenolol hydrochloride
  • HY-14558R
    Tandospirone (Standard)
    		Agonist
    Tandospirone (Standard) is the analytical standard of Tandospirone. This product is intended for research and analytical applications. Tandospirone (SM-3997) is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.
    Tandospirone (Standard)
  • HY-106157A
    Donitriptan mesylate
    		Agonist
    Donitriptan Mesylate is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively.
    Donitriptan mesylate
  • HY-101638A
    (±)-Fabesetron
    		Antagonist
    (±)-Fabesetron ((±)-FK1052 free base) is the racemate of Fabesetron, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
    (±)-Fabesetron
  • HY-B0115S
    Pizotyline-d3
    		Antagonist
    Pizotyline-d3 is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
    Pizotyline-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity