2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173055
    Ferroleuton
    		Inhibitor
    Ferroleuton is a competitive, selective inhibitor for 5-lipoxygenase with an IC50 of 0.21 μM. Ferroleuton exhibits antioxidant activity in DPPH (scavenges 86% DPPH-H at 50 μM), ABTS (EC50=19.42 μM) and FRAP (EC50=3.32 μM) assays.
    Ferroleuton
  • HY-122980
    Myxochelin A
    		Inhibitor
    Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.
    Myxochelin A
  • HY-14164S
    Zileuton-d4
    		Inhibitor
    Zileuton-d4 is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].
    Zileuton-d<sub>4</sub>
  • HY-N0198R
    Nordihydroguaiaretic acid (Standard)
    		Inhibitor
    Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
    Nordihydroguaiaretic acid (Standard)
  • HY-117853
    Atreleuton
    		Inhibitor
    Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation. Atreleuton is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Atreleuton
  • HY-101945
    A-69412
    		Inhibitor
    A-69412 is a reversible, specific inhibitor of the 5-lipoxygenase (5-LO). A-69412 has the potential to treat asthma and ulcerative colitis, and possibly other inflammatory and allergic conditions.
    A-69412
  • HY-W012399R
    2,5-Di-tert-butylhydroquinone (Standard)
    		Modulator
    2,5-Di-tert-butylhydroquinone (Standard)
  • HY-173056
    Ruthenoleuton
    		Inhibitor
    Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. Ruthenoleuton has antioxidant activity and can be used in the research of inflammatory diseases.
    Ruthenoleuton
  • HY-N12231
    Carbazomycin B
    		Inhibitor
    Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µMsup>[2]sup>[3]sup>[4].
    Carbazomycin B
  • HY-117973
    L 691816
    		Inhibitor
    L 691816 is a potent, selective and orally active inhibitors of 5-lipoxygenase. L 691816 can be used for the research of allergies and asthma.
    L 691816
  • HY-170957
    5-LOX/NO-IN-1
    		Inhibitor
    5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC50 of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects.
    5-LOX/NO-IN-1
  • HY-120303
    LY269415
    		Inhibitor
    LY269415, is an anti-oxidant agent, is a potent and orally active iron dependent lipid peroxidation and 5-lipoxygenase enzyme inhibitor. LY269415 has anti-inflammatory effects.
    LY269415
  • HY-153930
    h15-LOX-2 inhibitor 1
    		Inhibitor
    h15-LOX-2 inhibitor 1 (Comp 105) is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC50 of 0.34 μM.
    h15-LOX-2 inhibitor 1
  • HY-10437A
    Setileuton tosylate
    		Inhibitor
    Setileuton tosylate is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively.
    Setileuton tosylate
  • HY-147951
    COX-2/5-LOX-IN-3
    		Inhibitor
    COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases.
    COX-2/5-LOX-IN-3
  • HY-105983A
    CBS-1114 hydrochloride
    		Inhibitor
    CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor. CBS-1114 hydrochloride has the potential for inflammation and inflammation-related disorders research.
    CBS-1114 hydrochloride
  • HY-N2176R
    S-(+)-Marmesin (Standard)
    		Inhibitor
    S-(+)-Marmesin (Standard) is the analytical standard of S-(+)-Marmesin. This product is intended for research and analytical applications. S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
    S-(+)-Marmesin (Standard)
  • HY-B0881R
    Acetohexamide (Standard)
    		Inhibitor
    Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications, and inhibits the synthesis of 12(S)-HETE.
    Acetohexamide (Standard)
  • HY-112532A
    REV 5901 hydrochloride
    		Inhibitor
    REV 5901 hydrochloride is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved.
    REV 5901 hydrochloride
  • HY-118268
    RG 6866
    		Inhibitor
    RG 6866 is a 5-lipoxygenase (5-LOX) inhibitor with the potential to inhibit coronary artery constriction and negative cardiac inotropic effects in cardiac inflammatory states. When the heart is stimulated by antigens, RG 6866 can block the antigen-induced reduction in coronary flow in the heart.
    RG 6866
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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