2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0881R
    Acetohexamide (Standard)
    		Inhibitor
    Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications. 0
    Acetohexamide (Standard)
  • HY-112532A
    REV 5901 hydrochloride
    		Inhibitor
    REV 5901 hydrochloride is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved.
    REV 5901 hydrochloride
  • HY-118268
    RG 6866
    		Inhibitor
    RG 6866 is a 5-lipoxygenase (5-LOX) inhibitor with the potential to inhibit coronary artery constriction and negative cardiac inotropic effects in cardiac inflammatory states. When the heart is stimulated by antigens, RG 6866 can block the antigen-induced reduction in coronary flow in the heart.
    RG 6866
  • HY-156722
    ER-34122
    		Inhibitor
    ER-34122 is a dual 5-lipoxygenase/cyclooxygenase inhibitor with oral activity. ER-34122 has anti-inflammatory activity.
    ER-34122
  • HY-121987A
    (±)15-HEDE
    		Inhibitor
    (±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM).
    (±)15-HEDE
  • HY-161908
    h15-LOX-2 inhibitor 3
    		Inhibitor
    h15-LOX-2 inhibitor 3 (Compound 13) is an inhibitor of h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.
    h15-LOX-2 inhibitor 3
  • HY-120606
    A-78773
    		Inhibitor
    A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB4 in human whole blood and human neutrophils, with IC50 values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases.
    A-78773
  • HY-133215
    Zileuton sulfoxide
    		Inhibitor
    Zileuton sulfoxide is a sulfoxide derivative of Zileuton (HY-14164), a potent and selective inhibitor of lipoxygenase 5-LOX with anti-asthmatic properties.
    Zileuton sulfoxide
  • HY-119086
    L-651392
    		Inhibitor
    L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis.
    L-651392
  • HY-116164
    A-79175
    		Inhibitor
    A-79175 is a potent 5-lipoxygenase inhibitor that inhibits leukotriene formation. A-79175 is promising for research of various allergic and inflammatory diseases including asthma, allergic rhinitis, rheumatoid arthritis and inflammatory bowel disease.
    A-79175
  • HY-113691
    (E)-L-652343
    (E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer.
    (E)-L-652343
  • HY-106897
    BF389
    		Inhibitor
    BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research.
    BF389
  • HY-118848
    A63162
    		Inhibitor
    A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease.
    A63162
  • HY-117853S
    Atreleuton-d4
    		Inhibitor
    Atreleuton-d4 (ABT-761-d4; VIA-2291-d4) is deuterium-labeled Atreleuton (HY-117853).
    Atreleuton-d<sub>4</sub>
  • HY-161907
    h15-LOX-2 inhibitor 2
    		Inhibitor
    h15-LOX-2 inhibitor 2 (Compound 10) is an inhibitor of h15-LOX, with IC50 and Ki values of 26.9 μM and 16.4 μM, respectively.
    h15-LOX-2 inhibitor 2
  • HY-19023
    L-651896
    		Inhibitor
    L-651896 is a compound with anti-inflammatory and antiproliferative activities that inhibits 5-lipoxygenase and cyclooxygenase, thereby reducing the production of leukotrienes and prostaglandins. L-651896 can be used in the study of skin diseases and other inflammatory diseases.
    L-651896
  • HY-123391
    PD 127443
    		Inhibitor
    PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity.
    PD 127443
  • HY-N3073
    Picralinal
    		Inhibitor
    Picralinal (Picraline, 16-de(acetoxymethyl)-16-formyl-) is a Triterpenoids product that can be isolated from the whole plants of Scilla scilloides..
    Picralinal
  • HY-169138
    ZD 2138
    		Inhibitor
    ZD 2138 is an inhibitor of 5-lipoxygenase. ZD-2138 can alleviate bronchoconstriction induced by aspirin (HY-14654) and can be used in asthma research.
    ZD 2138
  • HY-155244
    12R-LOX-IN-2
    		Inhibitor 99.85%
    12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.
    12R-LOX-IN-2
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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