2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. Sigmoidin B

Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties.

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Sigmoidin B Chemical Structure

Sigmoidin B Chemical Structure

CAS No. : 87746-47-2

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Sigmoidin B Related Antibodies

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Description

Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2].

IC50 & Target[1]

5-Lipoxygenase

 

In Vivo

In the assay of phospholipase A2-induced mouse paw oedema, Sigmoidin B (5 mg/kg, ip) inhibits oedema formation at 60 min. In the Phorbol 12-myristate 13-acetate (PMA) (HY-18739) test, Sigmoidin B decreases the induced oedema by 83%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

356.37

Formula

C20H20O6
CAS No.
SMILES

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(C/C=C(C)\C)=C(C(O)=C3)O)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sigmoidin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigmoidin B87746-47-2LipoxygenaseLOX5-lipoxygenase inhibitorprenylated flavanoneDPPH radicalanti-inflammatory activity and antioxidant propertiesInhibitorinhibitorinhibit

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